PRENATAL BLOOD AND BONE LEAD EFECTS ON INFANT OCULOMOTOR FUNCTION

产前血液和骨铅对婴儿动眼功能的影响

• 批准号: 6107217
• 负责人: STEPHEN J ROTHENBERG
• 金额: $ 6.76万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6107217
• 关键词: X ray spectrometry; atomic absorption spectrometry; clinical research; embryo /fetus toxicology; gestational age; human pregnant subject; human subject; infant human (0-1 year); lead; prenatal diagnosis; prenatal stress; psychomotor function; questionnaires; saccades; smooth pursuit eye movement; statistics /biometry

The project will investigate the role of prepregnancy maternal bone lead and prenatal maternal blood lead upon alterations in infant saccadic and smooth pursuit eye movements. The project will study a traditionally underserved, primarily Latino and African-American inner city population in South Central Los Angeles at the King/Drew Medical Center. The target population has higher blood lead levels than the national average. The study seeks to determine if maternal blood lead during specific periods of pregnancy, representing different phases of fetal development, are more highly correlated with altered oculomotor function than maternal blood lead at other periods of pregnancy. It will determine if the effects of prenatal lead exposure can be measured from six months to two years of age. It will also see if postnatal blood lead levels predict altered oculomotor function. The study will determine if maternal bone lead contributes to altered oculomotor development with or without influence upon maternal blood lead level during pregnancy. It will determine which of the two lead exposure indices better predict developmental deficit. Mothers will be recruited near the end of one pregnancy and followed until their next pregnancy to obtain a prepregnancy bone lead. Maternal blood lead will be measured in the interpregnancy interval and during pregnancy while maternal bone lead will be measured only during the interpregnancy interval. Infant blood lead will be measured every 6 months from birth. Blood lead will be measured by atomic absorption spectrometry with graphite furnace. Bone lead will be measured by K-band X-ray fluorescence with 109Cd source, fast spectroscopy amplifier and advanced spectral analysis algorithms. Oculomotor function will be measured by infrared pupil-corneal reflection television scanner with automatic head tracking. Saccade parameters of latency and accuracy will be measured, along with smooth pursuit parameters of velocity gain using step-ramp horizontally displaced visual targets. Multiple regression techniques will be used to control for confounding and control variables, such as nutrition, illness and injury, in order to test the effects of the lead measures upon oculomotor function. Oculomotor function is a vital behavior that allows the infant to orient itself to acquire visual information. This function is primary to adequate development of the child. The tests are culture- free and validation of lead effect upon them will permit their wider use in any population. Bone lead measurements may supplement traditional blood lead measurements in determining exposure limits for regulatory purposes.

该项目将调查孕前母体骨铅的作用 和产前母体血铅对婴儿扫视和 流畅的追踪眼球运动 该项目将研究传统的 服务不足，主要是拉丁裔和非洲裔美国人的内城人口 在洛杉矶中南部的金德鲁医疗中心 目标 中国人的血铅水平高于全国平均水平。 的 一项研究旨在确定在特定时期， 怀孕，代表胎儿发育的不同阶段， 与母血相比， 在怀孕的其他时期。 它将决定 产前铅暴露可以从六个月到两年的时间来测量， 年龄 它还将观察出生后血铅水平是否预示着改变 眼功能 这项研究将确定母亲的骨铅是否 有助于改变眼发育，有或没有影响 对孕妇血铅水平的影响。 它将决定 两个铅暴露指数中的一个能更好地预测发育缺陷。 母亲们将在一次怀孕即将结束时被招募，并被跟踪到 他们的下一次怀孕，以获得孕前骨铅。 母体血液 将在判读间期和妊娠期间测量铅 而母体骨铅仅在解释期间测量 interval. 婴儿出生后每6个月测量一次血铅。 血铅将通过原子吸收光谱法测量， 石墨炉 骨铅测定采用K波段X射线荧光法 采用109 Cd源、快速光谱放大器和先进的光谱分析技术， 分析算法 眼功能将通过红外线测量 具有自动头部跟踪的瞳孔角膜反射电视扫描仪。 将测量潜伏期和准确性的扫视参数，沿着 水平步进斜坡法平滑速度增益追踪参数 移动的视觉目标 多元回归技术将用于 控制混杂和控制变量，如营养、疾病 和伤害，以测试铅措施的影响， 眼功能 视觉功能是一种重要的行为， 婴儿定向自己以获取视觉信息。 此函数 对儿童的充分发展至关重要。 测试是培养- 对它们的铅效应进行免费和验证，将使它们得到更广泛的应用 在任何人口。 骨铅测量可以补充传统的 血铅测定在确定管制接触限值中的作用 目的