PRENATAL BLOOD AND BONE LEAD EFECTS ON INFANT OCULOMOTOR FUNCTION

产前血液和骨铅对婴儿动眼功能的影响

• 批准号: 6240117
• 负责人: STEPHEN J ROTHENBERG
• 金额: $ 4.33万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6240117
• 关键词: X ray spectrometry; atomic absorption spectrometry; clinical research; embryo /fetus toxicology; gestational age; human pregnant subject; human subject; infant human (0-1 year); lead; prenatal diagnosis; prenatal stress; psychomotor function; questionnaires; saccades; smooth pursuit eye movement; statistics /biometry

The project will investigate the role of prepregnancy maternal bone lead and prenatal maternal blood lead upon alterations in infant saccadic and smooth pursuit eye movements. The project will study a traditionally underserved, primarily Latino and African-American inner city population in South Central Los Angeles at the King/Drew Medical Center. The target population has higher blood lead levels than the national average. The study seeks to determine if maternal blood lead during specific periods of pregnancy, representing different phases of fetal development, are more highly correlated with altered oculomotor function than maternal blood lead at other periods of pregnancy. It will determine if the effects of prenatal lead exposure can be measured from six months to two years of age. It will also see if postnatal blood lead levels predict altered oculomotor function. The study will determine if maternal bone lead contributes to altered oculomotor development with or without influence upon maternal blood lead level during pregnancy. It will determine which of the two lead exposure indices better predict developmental deficit. Mothers will be recruited near the end of one pregnancy and followed until their next pregnancy to obtain a prepregnancy bone lead. Maternal blood lead will be measured in the interpregnancy interval and during pregnancy while maternal bone lead will be measured only during the interpregnancy interval. Infant blood lead will be measured every 6 months from birth. Blood lead will be measured by atomic absorption spectrometry with graphite furnace. Bone lead will be measured by K-band X-ray fluorescence with 109Cd source, fast spectroscopy amplifier and advanced spectral analysis algorithms. Oculomotor function will be measured by infrared pupil-corneal reflection television scanner with automatic head tracking. Saccade parameters of latency and accuracy will be measured, along with smooth pursuit parameters of velocity gain using step-ramp horizontally displaced visual targets. Multiple regression techniques will be used to control for confounding and control variables, such as nutrition, illness and injury, in order to test the effects of the lead measures upon oculomotor function. Oculomotor function is a vital behavior that allows the infant to orient itself to acquire visual information. This function is primary to adequate development of the child. The tests are culture- free and validation of lead effect upon them will permit their wider use in any population. Bone lead measurements may supplement traditional blood lead measurements in determining exposure limits for regulatory purposes.

该项目将调查孕前母体骨铅的作用 和产前母血导致婴儿扫视和眼跳变化 平滑的追踪眼球运动。 该项目将研究传统的 服务不足，主要是拉丁裔和非裔美国人内城人口 位于洛杉矶中南部的金/德鲁医疗中心。 目标 人口血铅水平高于全国平均水平。 这 研究旨在确定母亲在特定时期的血液中是否含有铅 怀孕代表胎儿发育的不同阶段， 与母体血液相比，与动眼功能改变高度相关 怀孕其他时期的铅。 它将决定是否影响 产前铅暴露可在六个月至两年内进行测量 年龄。 它还将了解产后血铅水平是否预示着变化 动眼神经功能。 该研究将确定母体骨铅是否 有助于改变动眼神经发育，有或没有影响 怀孕期间母亲血铅水平。 它将决定哪个 两个铅暴露指数中的一个可以更好地预测发育缺陷。 母亲将在一次怀孕即将结束时被招募并进行跟踪，直到 他们在下次怀孕时获得孕前骨铅。 母血 将在怀孕间隔和怀孕期间测量铅 而母体骨铅仅在怀孕期间进行测量 间隔。 婴儿出生后每 6 个月测量一次血铅。 血铅将通过原子吸收光谱法测量 石墨炉。 骨铅将通过 K 波段 X 射线荧光测量 配备 109Cd 光源、快速光谱放大器和先进的光谱 分析算法。 通过红外线测量动眼功能 具有自动头部跟踪功能的瞳孔-角膜反射电视扫描仪。 将测量延迟和准确性的扫视参数，以及 使用水平阶梯斜坡平滑追踪速度增益参数 视觉目标移位。 将使用多元回归技术 控制混杂变量和控制变量，例如营养、疾病 和伤害，以测试铅措施对 动眼神经功能。 动眼功能是一种重要的行为，它允许 婴儿引导自己获取视觉信息。 这个功能 是孩子充分发展的首要条件。 测试是文化- 免费并验证铅对它们的影响将允许它们更广泛的使用 在任何人群中。 骨铅测量可以补充传统的 血铅测量确定监管暴露限值 目的。