SLEEP, DEPRESSION, AND HEALTH RELATED BEHAVIORS

睡眠、抑郁和健康相关行为

• 批准号: 6107271
• 负责人: ROBERT A HICKS
• 金额: $ 11.75万
• 依托单位: SAN JOSE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6107271
• 关键词: REM sleep; behavioral /social science research tag; clinical research; depression; electroencephalography; electromyography; electrophysiology; health behavior; human subject; laboratory rat; learned helplessness; passive smoking; questionnaires; sleep; sleep deprivation; stress; tobacco abuse

The research planned for this grant period includes eight separate studies. All of these studies are designed to measure relationships between aspects of sleep and health-related behaviors. For the most part, each of these studies will generate new, and perhaps important, data that should provide useful insights into the health problems that will be considered. Four of these studies focus on using the demonstrated links between sleep and endogenous depression to provide further and needed validation of two major animal models of human depression (i.e., the behavioral despair and learned helplessness models). Specifically, two of these studies are designed to determine whether the induction of either behavioral despair or learned helplessness alters the architecture of sleep in a manner that is consistent with the deviations from normal electrophysiological patterns that characterize the sleep of patients with endogenous depression. The other two studies in this set are designed to measure the effects of REM sleep depression (i.e., a manipulation that has antidepressant effects) on the depressive-like behaviors that rats exhibit subsequent to the induction of either behavioral despair or learned helplessness. The need for valid animal models of human depression is important and obvious. The significance of this set of studies is that their results may provide less ambiguous support for the validity of one or both of these procedures and in so doing, increase confidence in their usefulness in the study of antidepressant treatments. In addition to this set of four studies, two studies using laboratory animals, are proposed to clarify issues that arise from the application of the procedures for one or both of these models, that is, the sensitivity to pain and fearfulness. The results of these studies should enhance the ability to interpret data derived using either of these animal models of human depression. Finally, two large scale questionnaire studies have been proposed. One of these seeks to gain information that is relevant to the understanding and the remediation of the alarming reductions in both the sleep quantity and quality of college students that we have documented over the past two decades, using, for the first time, a design that considers both gender and ethnic identity as variables. The other questionnaire is an amplification of our recently published research that is designed to comprehensively measure the relationships between cigarette smoking and the quantity and the quality of sleep in a manner that permits the covariation of certain factors that have confounded the interpretation of the relationships between cigarette smoking and sleep in previously published studies. Thus the knowledge generated by both of these questionnaire studies should prove to be useful in altering behaviors that may lead to sleep problems.

该研究计划在此期间，包括八个独立的 问题研究 所有这些研究都是为了衡量 睡眠和健康相关行为之间的联系。 在大多数情况下， 这些研究中的每一项都将产生新的，也许是重要的数据， 应该提供有益的见解，健康问题， 考虑了 其中四项研究侧重于使用所演示的链接 睡眠和内源性抑郁症之间的联系， 两种主要的人类抑郁症动物模型的验证（即，的 行为绝望和习得性无助模型）。 具体来说，两个 这些研究旨在确定诱导 行为绝望或习得性无助改变了 睡眠的方式是与正常的偏差一致 电生理模式，表征患者的睡眠， 内源性抑郁 本系列中的其他两项研究旨在 测量REM睡眠抑制的影响（即，这种操纵 抗抑郁作用）对大鼠表现出的抑郁样行为的影响 在诱导行为绝望或习得性绝望之后， 无奈 需要有效的人类抑郁症动物模型， 重要且显而易见。 这组研究的意义在于 他们的研究结果可能会为一个人的有效性提供更明确的支持， 或这两种程序，并在这样做，增加他们的信心， 在抗抑郁治疗研究中的应用。 除此之外 一组四项研究，两项使用实验室动物的研究， 澄清适用程序中出现的问题， 或者这两种模型都有，也就是说，对痛苦和恐惧的敏感性。 这些研究的结果应能提高解释数据的能力 使用这些人类抑郁症的动物模型中的任何一个得出。 最后， 已提出两项大规模问卷调查研究。 其中一 寻求获得与理解和 补救睡眠量和睡眠时间的惊人减少， 我们在过去两年中记录的大学生的素质 几十年来，第一次使用一种考虑到性别的设计， 和种族认同作为变量。 另一份问卷是 扩大我们最近发表的研究，旨在 全面衡量吸烟与 睡眠的数量和质量， 某些因素的协变混淆了对 吸烟和睡眠之间的关系在以前 发表的研究。 这两种知识的产生， 问卷调查应该被证明是有用的，在改变行为， 可能导致睡眠问题。