Determining how CD4+ T cells regulate adult liver stem cells during regeneration

确定 CD4 T 细胞在再生过程中如何调节成体肝干细胞

• 批准号: MR/T030798/1
• 负责人: Wei-Yu Lu
• 金额: $ 171.47万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT030798%2F1
• 关键词: Determining; how; CD4+; cells; regulate

The liver normally recovers after injury in most situations through the division of hepatocytes, but this is fundamentally impaired during chronic liver injury. During chronic liver injury, bile ducts in the liver react in response to liver damage. This process is important for liver regeneration as some cells of the bile ducts can become hepatocytes when the liver is severely injured. However, the factors that control this process remain unknown. Immune cells infiltrate the liver and are observed close to the bile cuts during chronic liver injury and my initial data suggest that these immune cells control can affect how the liver regenerate. In this project I will use multiple models of human liver disease to investigate what type of immune cells are involved and how they interact with bile ducts to control liver regeneration. This research will enable the design of new therapies to treat chronic liver diseases which is currently a major issue worldwide.

在大多数情况下，肝脏通常通过肝细胞的分裂在损伤后恢复，但这在慢性肝损伤期间从根本上受损。在慢性肝损伤期间，肝脏中的胆管对肝损伤作出反应。这个过程对于肝脏再生很重要，因为当肝脏严重损伤时，胆管的一些细胞可以变成肝细胞。然而，控制这一过程的因素仍然未知。在慢性肝损伤期间，免疫细胞浸润肝脏并在胆汁切口附近观察到，我的初步数据表明这些免疫细胞控制可以影响肝脏再生。在这个项目中，我将使用多种人类肝脏疾病模型来研究参与的免疫细胞类型以及它们如何与胆管相互作用以控制肝脏再生。这项研究将有助于设计治疗慢性肝病的新疗法，这是目前全球面临的一个主要问题。

项目成果

Inhibition of nuclear factor (erythroid-derived 2)-like 2 promotes hepatic progenitor cell activation and differentiation.

• DOI: 10.1038/s41536-021-00137-z
• 发表时间: 2021-05-26
• 期刊: NPJ Regenerative medicine
• 影响因子: 7.2
• 作者: Bellanti F;di Bello G;Iannelli G;Pannone G;Pedicillo MC;Boulter L;Lu WY;Tamborra R;Villani R;Vendemiale G;Forbes SJ;Serviddio G
• 通讯作者: Serviddio G