开发用于治疗弗里德赖希共济失调的铁络合物-猫眼课题宝

开发用于治疗弗里德赖希共济失调的铁络合物

批准号：

nhmrc : 1002867

负责人：

Dr Yohan Suryo Rahmanto

金额：

$41.08万

依托单位：

The University of Sydney

依托单位国家：

澳大利亚

项目类别：

Project Grants

财政年份：

2011

资助国家：

澳大利亚

项目状态：

已结题

起止时间：

2011-01-01 至 2014-12-31

来源：

https://researchdata.edu.au/development-iron-complexes-iron-metabolism/108866

关键词：

Development Iron Complexes Treatment Friedreich

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英文摘要

Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal could lead to novel therapies for FA

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