Alpha-2-Macroglobulin and the Transport and Uptake of the Hormone, Hepcidin

Alpha-2-巨球蛋白与激素铁调素的运输和摄取

• 批准号: nhmrc : 632698
• 负责人: Dr Yohan Suryo Rahmanto
• 金额: $ 35.58万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/alpha-2-macroglobulin-hormone-hepcidin/96151
• 关键词: Alpha; Macroglobulin; Transport; Uptake; Hormone

Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.

铁调素是一种肽激素，是铁代谢的主要调节剂。已经表明铁调素在血液中是游离的。然而，我们最近发现铁调素与血浆中的α-2-巨球蛋白（α 2-M）结合，这增加了该肽的功效。α 2-M在铁调素生物学中发挥作用的证明将有助于更好地了解铁调素生理学、开发其测量方法并改善铁相关疾病的治疗。