INTEGRATED CELLULAR FLUORESCENCE ANALYSIS FACILITY

集成细胞荧光分析设备

• 批准号: 2503115
• 负责人: John R Raymond
• 金额: $ 28.09万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2503115
• 关键词: biomedical equipment; biomedical equipment purchase; flow cytometry; fluorimetry; lasers

The purpose of this proposal is to obtain equipment to create an integrated Cellular Fluorescence Analysis Facility at the Medical University of South Carolina (MUSC). The key components of the proposed facility are a Fluorometric Laser Imaging Plate Reader (FLIPR) and a FACSCalibur Analytical Flow Cytometer. This facility is requested by a group of 11 major users in three colleges (Medicine, Dental Medicine, and Pharmaceutical Sciences) and 6 departments within the College of Medicine (Medicine, Microbiology, Pharmacology, Pathology, Physiology, and Experimental Oncology). The specific aims are as follows: 1. To obtain a Fluorometric Laser Imaging Plate Reader (FLIPR) and a FACSCalibur Analytical Flow Cytometer for the MUSC Cellular Fluorescence Analysis Facility. 2. To use this facility to enhance the productivity of NIH-funded investigators and to improve the research efficiency and competitiveness of MUSC research and trainees. 3. To use this facility to foster interdisciplinary work among the users. The facility addresses a broad need for flexible and high throughput fluorescence analyses to support research in many different disciplines. A detailed organizational plan, substantial institutional commitment of support, and a long term plan for maintenance ensures the sustained viability of the facility. The availability of the integrated Cellular Fluorescence Analysis Facility will provide unique opportunities for the development of novel new uses for cellular fluorescence detection methodologies. It will serve as a platform for interdisciplinary investigation and training, and will significantly enhance the competitiveness of MUSC investigators.

本提案的目的是获得设备来创建一个

项目成果

Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy.

• DOI: 10.1021/jm801072v
• 发表时间: 2009-04
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: K. S. Orwig;McKensie R. Lassetter;M. Hadden;Thomas A. Dix