EXTRAMURAL RESEARCH FACILITIEIS CONSTRUCTION

描述(申请人提供)：本申请申请金额为200万美元 从国家研究资源中心(NCRR)到适合外壳空间的 七楼BSB的增设，并对其进行升级消毒和相关 现有BSB七楼动物设施的支持设施，创建 一个最先进的水平一体化啮齿动物设施。长期的 目标是扩大MUSC的开发和利用能力 人类疾病基因工程小鼠模型被列为国家重点 区域。具体目标是：1)提供最先进的啮齿动物设施 有利于提高互动、效率和生产力 通过集中转基因动物的计划进行调查；2) 提供五个新的动物饲养套房和一个转基因实验室套房 AAALAC认证的具有BSL2能力的动物设施；以及3)翻新 现有的BSB笼式清洗和高压灭菌区。 受益者是南加州大学五个不同基础科学领域的教职员工 正在进行由13个不同部门资助的尖端研究的部门 美国国立卫生研究院(NIH)。这笔赠款将使它 可能促进招募更多由NIH资助的调查人员 依赖动物模型；取消目前由NIH资助的限制 目前必须设计他们的实验和方法的研究人员 围绕现有资源，加快青少年职业发展 调查人员；改善研究生的研究培训机会 和博士后研究员；使MUSC在机构方面更具竞争力 通过提高教员和受训人员的素质提供培训补助金；以及 保持对实验动物设施的认可。项目总成本 为4,212,617美元，其中该大学的份额为53%。

DESCRIPTION (provided by applicant): This application requests $2 million from National Center for Research Resources (NCRR) to fit-out shell space on the seventh floor of the BSB Addition, and to upgrade sanitization and related support facilities in the existing BSB seventh floor animal facility, creating a state-of-the-art horizontally integrated rodent facility. The long-term objective is to expand MUSC's capacity for development and utilization of genetically engineered mouse models of human disease in national priority areas. Specific Aims are: 1) to provide state-of-the-art rodent facilities conducive to increasing interaction, efficiency and productivity among investigators by centralizing the program for transgenic animals; 2) to provide five new animal holding suites and a transgenic laboratory suite in an AAALAC-accreditable animal facility with BSL2 capability; and 3) to renovate the existing BSB cage wash and autoclave area. The beneficiaries are MUSC faculty members in five different basic science departments who are conducting, cutting-edge research funded by 13 different institutes of the National Institutes of Health (NIH). The grant will make it possible to facilitate recruitment of additional NIH-funded investigators who rely on animal models; remove constraints from present NIH-funded investigators who currently must design their experiments and methodology around available resources; accelerate the career development of junior investigators; improve research training opportunities for graduate students and postdoctoral fellows; make MUSC more competitive for institutional training grants by virtue of increased quality of faculty and trainees; and maintain accreditations for laboratory animal facilities. Total project cost is $4,212,617, of which the University's share is 53 percent.