EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

描述（由申请人提供）： 这是一个新的应用程序，要求从国家研究资源中心（NCRR）3,171,444美元，以完成儿童研究所（CRI）两层楼的带壳空间121,000平方米。30英尺，正在建设中的实验室大楼毗邻基础科学大楼（BSB）。 第五层和第六层的建成将创造空间：1）作为发育神经科学和心血管发育生物学两个多部门，跨学科研究计划的物理中心; 2）建立脂质组学，细胞分选，组织工程和组织学的尖端核心设施，以维持和扩大PHS支持的研究; 3）促进和促进整个MUSC的医生科学家和基础科学家的更多生物医学研究和培训，他们可以获得儿童和发育疾病和障碍的分子和遗传基础的经验和理解。 该研究涉及国家在儿童健康和疾病、正常发育以及可能具有胎儿或早期发育起源作为其发病机制一部分的慢性疾病方面的优先事项。 拟议的项目将解决MUSC研究空间的三个主要缺陷：1）研究空间不足和功能失调，2）空间限制，3）核心资源分散。 主要受益者是来自四个部门（儿科，神经病学，生物化学和细胞生物学）的教职员工，以及学生，博士后研究员和合作者。 该项目将促进招募一名具有神经元细胞谱系发育专业知识的神经生物学家、一名高级分子生物学家和人类遗传学家、一名干细胞生物学家以及一名或多名具有生物基质和/或生物反应器专业知识的组织工程师。 项目总成本为6，342，887美元;大学贡献了3，171，443美元（50%）。

DESCRIPTION (provided by applicant): This is a new application requesting $3,171,444 from National Center for Research Resources (NCRR) to complete shelled space on two floors of the Children's Research Institute (CRI) a 121,000 sq. ft, laboratory building under construction adjoining the Basic Science Building (BSB). The completion of the fifth and sixth floors as proposed will create space to: 1) serve as the physical center for two multi-departmental, interdisciplinary research programs in developmental neuroscience and cardiovascular developmental biology; 2) establish cutting-edge core facilities in lipidomics, cell sorting, tissue engineering, and histology to maintain and expand PHS-supported research; 3) facilitate and foster more biomedical research and training of both physician scientists and basic scientists throughout MUSC who can gain experience and understanding of the molecular and genetic basis of diseases and disorders of childhood and development. The research addresses national priorities in children's health and diseases, normal development, and chronic diseases that may have a fetal or early developmental origin as part of their pathogenesis. The proposed project will address three major deficiencies in research space at MUSC: 1) inadequate and dysfunctional research space, 2) space constraints, and 3) dispersion of core resources. The primary beneficiaries are faculty members from four departments (Pediatrics, Neurology, Biochemistry, and Cell Biology), as well as students, postdoctoral fellows, and collaborators. The project will facilitate the recruitment of a neurobiologist with expertise in neuronal cell lineage development, a senior molecular biologist and human geneticist, a stem cell biologist, and one or more tissue engineer(s) with expertise in biomatrices and/or bioreactors. The total project cost is $6,342,887; the University is contributing $3,171,443 (50 percent).