EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

描述(由申请人提供)： 这是一项新的申请，要求国家研究资源中心(NCRR)提供3,171,444美元，以完成儿童研究所(CRI)两层楼的炮击空间，面积为121,000平方米。FT，毗邻基础科学大楼(BSB)的在建实验室大楼。拟议中的第五层和第六层的建成将创造以下空间：1)作为发育神经科学和心血管发育生物学两个多部门、跨学科研究项目的物理中心；2)建立脂质组学、细胞分选、组织工程和组织学方面的尖端核心设施，以维持和扩大PHS支持的研究；3)促进和促进更多的生物医学研究，并在整个MUSC对内科科学家和基础科学家进行培训，他们能够获得经验和了解儿童疾病和发育障碍的分子和遗传学基础。这项研究涉及国家在儿童健康和疾病、正常发育和慢性疾病方面的优先事项，这些疾病可能源于胎儿或早期发育，是其发病机制的一部分。拟议的项目将解决南加州大学研究空间的三大不足：1)研究空间不足和功能失调，2)空间限制，3)核心资源分散。主要受益者是来自四个系(儿科、神经病学、生物化学和细胞生物学)的教职员工，以及学生、博士后研究员和合作者。该项目将促进招聘一名具有神经细胞谱系发展专长的神经生物学家、一名资深分子生物学家和人类遗传学家、一名干细胞生物学家以及一名或多名具有生物特效和/或生物反应堆专长的组织工程师(S)。项目总成本为6,342,887美元；该大学将捐赠3,171,443美元(50%)。

DESCRIPTION (provided by applicant): This is a new application requesting $3,171,444 from National Center for Research Resources (NCRR) to complete shelled space on two floors of the Children's Research Institute (CRI) a 121,000 sq. ft, laboratory building under construction adjoining the Basic Science Building (BSB). The completion of the fifth and sixth floors as proposed will create space to: 1) serve as the physical center for two multi-departmental, interdisciplinary research programs in developmental neuroscience and cardiovascular developmental biology; 2) establish cutting-edge core facilities in lipidomics, cell sorting, tissue engineering, and histology to maintain and expand PHS-supported research; 3) facilitate and foster more biomedical research and training of both physician scientists and basic scientists throughout MUSC who can gain experience and understanding of the molecular and genetic basis of diseases and disorders of childhood and development. The research addresses national priorities in children's health and diseases, normal development, and chronic diseases that may have a fetal or early developmental origin as part of their pathogenesis. The proposed project will address three major deficiencies in research space at MUSC: 1) inadequate and dysfunctional research space, 2) space constraints, and 3) dispersion of core resources. The primary beneficiaries are faculty members from four departments (Pediatrics, Neurology, Biochemistry, and Cell Biology), as well as students, postdoctoral fellows, and collaborators. The project will facilitate the recruitment of a neurobiologist with expertise in neuronal cell lineage development, a senior molecular biologist and human geneticist, a stem cell biologist, and one or more tissue engineer(s) with expertise in biomatrices and/or bioreactors. The total project cost is $6,342,887; the University is contributing $3,171,443 (50 percent).