Innovating functional colour changing photonic crystals - from gas sensors to tissue scaffolds

创新功能性变色光子晶体——从气体传感器到组织支架

• 批准号: MR/T042664/1
• 负责人: Izabela Jurewicz
• 金额: $ 145.68万
• 依托单位: Advanced Material Development
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT042664%2F1
• 关键词: Innovating; functional; colour; changing; photonic

Structurally coloured polymer-based photonic crystals enhanced with pristine graphene or other 2D related nanomaterials that can change colour upon external stimuli such as heat or mechanical pressure are promising for a range of novel and emerging sensing applications. These materials have the potential to disrupt several market sectors, yet work is still needed in developing the base technology and multidisciplinary commercial application of the resulting devices and products. The programme of work within this Future Leaders Fellowship will focus on the executive transition of the fellow from academia to industry and her leading further multidisciplinary developments and the subsequent commercial innovation of novel photonic crystal devices. Particular aims are to produce an ionizing radiation dosimeter with an effective atomic number similar to that of human tissue for accurate tissue equivalent dosimetry, a sensing device which changes vividly in colour upon exposure to toxic gas environment in civilian first responder applications as well as a novel in vitro tissue model, consisting of heart cells on a conductive photonic crystal scaffold, to create a commercially viable, functional, electrically stimulated, physiologically relevant, heart tissue scaffold.The economic and social impact of these will be widely felt. For example cheap and simple to use devices that can quantitatively and qualitatively detect the presence of toxic gases can save the lives of civilians and first responders responding to hazardous fire situations. A radiation dosimeter for careful radiation monitoring will protect radiation workers and patients from potential health risks, and contribute to enhancement of the health and safety standards, while the development of novel tissue scaffolds will enable easier design and testing of vaccines and drugs and significantly reduce the use of animals.

用原始石墨烯或其他2D相关纳米材料增强的结构着色的基于聚合物的光子晶体，可以在外部刺激（如热或机械压力）下改变颜色，有望用于一系列新颖和新兴的传感应用。这些材料有可能破坏几个市场部门，但仍需要努力开发基础技术和所得设备和产品的多学科商业应用。在这个未来的领导者奖学金的工作计划将集中在从学术界到工业界和她的领导进一步多学科的发展和新的光子晶体器件的后续商业创新的研究员的行政过渡。具体的目的是生产一种电离辐射剂量计，其有效原子序数类似于人体组织的原子序数，用于精确的组织等效剂量测定;一种感测装置，其在民用第一响应者应用中暴露于有毒气体环境时颜色生动地变化;以及一种新颖的体外组织模型，其由导电光子晶体支架上的心脏细胞组成，以产生商业上可行的、功能性的，电刺激，生理相关，心脏组织支架。这些的经济和社会影响将被广泛感受。例如，可以定量和定性检测有毒气体存在的廉价和简单易用的装置可以拯救平民和应对危险火灾情况的第一反应者的生命。用于仔细辐射监测的辐射剂量计将保护辐射工作人员和患者免受潜在的健康风险，并有助于提高健康和安全标准，而新型组织支架的开发将使疫苗和药物的设计和测试更加容易，并大大减少动物的使用。

项目成果

Pickering emulsions stabilised with oligoglycine-functionalised nanodiamond as a model system for ocular drug delivery applications.

用低聚甘氨酸功能化纳米金刚石稳定的皮克林乳液作为眼部药物输送应用的模型系统。

• DOI: 10.1039/d3sm00495c
• 发表时间: 2023
• 期刊: Soft matter
• 影响因子: 3.4
• 作者: Huang Z

Probing the interaction between 2D materials and oligoglycine tectomers

• DOI: 10.1088/2053-1583/ac92ec
• 发表时间: 2022-10-01
• 期刊: 2D MATERIALS
• 影响因子: 5.5
• 作者: Tripathi, Manoj;Garriga, Rosa;Munoz, Edgar
• 通讯作者: Munoz, Edgar

Electrical stimulation through conductive scaffolds for cardiomyocyte tissue engineering: Systematic review and narrative synthesis.

• DOI: 10.1111/nyas.14812
• 发表时间: 2022-09
• 期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
• 影响因子: 5.2
• 作者: Scott, Louie;Elidottir, Katrin;Jeevaratnam, Kamalan;Jurewicz, Izabela;Lewis, Rebecca
• 通讯作者: Lewis, Rebecca

Two-Dimensional Triblock Peptide Assemblies for the Stabilization of Pickering Emulsions with pH Responsiveness.

• DOI: 10.1021/acsami.2c17558
• 发表时间: 2022-11-30
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Huang, Zhiwei;Calicchia, Eleonora;Jurewicz, Izabela;Munoz, Edgar;Garriga, Rosa;Portale, Giuseppe;Howlin, Brendan J.;Keddie, Joseph L.
• 通讯作者: Keddie, Joseph L.

Biomimetic approach to articular cartilage tissue engineering using carbon nanotube-coated and textured polydimethylsiloxane scaffolds.

• DOI: 10.1111/nyas.14769
• 发表时间: 2022-07
• 期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
• 影响因子: 5.2
• 作者: Elidottir, Katrin Lind;Scott, Louie;Lewis, Rebecca;Jurewicz, Izabela
• 通讯作者: Jurewicz, Izabela