PRENATAL DIAGNOSIS OF CONGENITAL ANOMALIES
先天性异常的产前诊断
基本信息
- 批准号:6108124
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The goal of this project is to improve the diagnosis and treatment of
fetal disease. In the past, the Branch has pioneered the used of
thin-gauge embryo-fetoscopy and endoscopic fetal surgery for the
treatment of disorders of multiple gestation. This year the effort was
focused on examining the accuracy of dating of pregnancy in the
midtrimester.
Gestational age assessment is an integral part of prenatal care.
Inaccurate age assignment results in an increase in the rate of false
positive and false negative cases, diagnostic errors, and unnecessary
invasive procedures. The standard method of assigning duration of
pregnancy is menstrual age and accuracy is dependent upon the reliability
of menstrual history. However, as many as 45% of pregnant women had
sub-optimal menstrual history. By far, the most popular alternative
method of dating is fetal biometry with ultrasound. The Perinatology
Research Branch conducted a study in collaboration with the Cornell
University Medical Center to determine the accuracy of fetal biometry
between 14 and 22 weeks in the prediction of gestational age in
singleton, twin and triple gestations based upon population of patients
who conceived as a result of in vitro fertilization. The results of this
study demonstrated the size of the fetal head circumference was the most
accurate predictor of gestational age of all parameters studied. The
addition of one parameter (abdominal circumference or femur length) or
two (abdominal circumference and femur length) significantly improved the
accuracy of the prediction based on head circumference alone. The
clinical practice in most obstetrical units is that discrepancy between
gestational age by LMP disagrees by more than 14 days with that derived
from fetal biometry in the second trimester, the LMP assessment is
superseded by fetal biometry. Our study suggests that when a discrepancy
of more than 7 days exists between the two, the biometric prediction
should be given preference, provided there is no congenital anomaly or
severe growth delay.
A major finding of the study was that the dating formulae derived from
singleton gestations can be used for dating multiple pregnancies. A
simple average of the gestational age prediction of the two twins was
found to be an accurate predictor of age. In the case of triplets, one
day can be added to the average of the longest and shortest gestational
age prediction among the triplets. Our observations imply that fetuses
of twin gestations grow at a similar rate to singleton gestations during
the midtrimester. However, data on triplets between 20 and 22 weeks is
suggestive of a deceleration of growth, an issue which requires further
investigation. We observed that the difference in the gestational age
prediction among members of a multiple gestation averaged 2.2 days for
twins (maximum = 7.2 days) and 4.2 days for triplets (maximum = 10.8
days). Therefore, when the difference among members of multiple
gestation is two weeks or more, a search for fetal growth disorders,
congenital anomalies, or a measurement error is justified.
该项目的目的是提高诊断和治疗
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ROBERTO ROMERO其他文献
ROBERTO ROMERO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ROBERTO ROMERO', 18)}}的其他基金
CANDIDATE GENE ANALYSIS OF ADVERSE OBSTETRICAL OUTCOMES
不良产科结局的候选基因分析
- 批准号:
7420626 - 财政年份:2006
- 资助金额:
-- - 项目类别:
CANDIDATE GENE ANALYSIS OF ADVERSE OBSTETRICAL OUTCOMES
不良产科结局的候选基因分析
- 批准号:
7181280 - 财政年份:2005
- 资助金额:
-- - 项目类别:
The Role Of Subclinical Infection And Cytokines In Preterm Parturition
亚临床感染和细胞因子在早产中的作用
- 批准号:
8941476 - 财政年份:
- 资助金额:
-- - 项目类别:
The Role Of Subclinical Infection And Cytokines In Preterm Parturition
亚临床感染和细胞因子在早产中的作用
- 批准号:
7968617 - 财政年份:
- 资助金额:
-- - 项目类别:
The Role Of Subclinical Infection And Cytokines In Prete
亚临床感染和细胞因子在 Prete 中的作用
- 批准号:
7334071 - 财政年份:
- 资助金额:
-- - 项目类别:
The Role Of Subclinical Infection And Cytokines In Preterm Parturition
亚临床感染和细胞因子在早产中的作用
- 批准号:
8351155 - 财政年份:
- 资助金额:
-- - 项目类别:
相似海外基金
FAIRClinical: FAIR-ification of Supplementary Data to Support Clinical Research
FAIRClinical:补充数据的 FAIR 化以支持临床研究
- 批准号:
EP/Y036395/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
Optimizing integration of veterinary clinical research findings with human health systems to improve strategies for early detection and intervention
优化兽医临床研究结果与人类健康系统的整合,以改进早期检测和干预策略
- 批准号:
10764456 - 财政年份:2023
- 资助金额:
-- - 项目类别:
The IDeA State Consortium for a Clinical Research Resource Center: Increasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and WorkforceDevelopment
IDeA 州临床研究资源中心联盟:通过机会交流、有效营销和劳动力发展增加 IDeA 州的临床试验
- 批准号:
10715568 - 财政年份:2023
- 资助金额:
-- - 项目类别:
The Mayo Clinic NeuroNEXT Clinical Research Site
梅奥诊所 NeuroNEXT 临床研究网站
- 批准号:
10743328 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Addressing Underperformance in Clinical Trial Enrollments: Development of a Clinical Trial Toolkit and Expansion of the Clinical Research Footprint
解决临床试验注册表现不佳的问题:开发临床试验工具包并扩大临床研究足迹
- 批准号:
10638813 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Improving Multicultural Engagement in Clinical Research through Partnership with Federally Qualified Health Centers and Community Health Worker Programs
通过与联邦合格的健康中心和社区卫生工作者计划合作,改善临床研究中的多元文化参与
- 批准号:
10823828 - 财政年份:2023
- 资助金额:
-- - 项目类别:
The Minnesota TMD IMPACT Collaborative: Integrating Basic/Clinical Research Efforts and Training to Improve Clinical Care
明尼苏达州 TMD IMPACT 协作:整合基础/临床研究工作和培训以改善临床护理
- 批准号:
10828665 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Promoting a Culture Of Innovation, Mentorship, Diversity and Opportunity in NCI Sponsored Clinical Research: NCI Research Specialist (Clinician Scientist) Award Application of Janice M. Mehnert, M.D.
在 NCI 资助的临床研究中促进创新、指导、多样性和机会文化:Janice M. Mehnert 医学博士的 NCI 研究专家(临床科学家)奖申请
- 批准号:
10721095 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Clinical Research Center for REstoration of NEural-based Function in the Real World (RENEW)
现实世界神经功能恢复临床研究中心 (RENEW)
- 批准号:
10795328 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Clinical Research and Academic Success in Obstetrics & Gynecology
产科临床研究和学术成就
- 批准号:
10828252 - 财政年份:2023
- 资助金额:
-- - 项目类别: