Statistical modelling to characterise the dietary determinants of health outcomes in mothers and their children.

用于描述母亲及其子女健康结果的饮食决定因素的统计模型。

• 批准号: MR/V005839/1
• 负责人: Kathryn Dalrymple
• 金额: $ 15.01万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV005839%2F1
• 关键词: Statistical; modelling; characterise; dietary; determinants

Currently when scientists analyse dietary data, they look for relationships between dietary intake at one time point and either the health of a person at that time, or their health in later life. Although this can be useful, and is an approach that has informed many nutrition-related public health strategies, recent developments in statistical sciences are available that should help provide greater insights, by looking at repeated measurements of dietary data over time. The aim of this award is to develop methodologies for this innovative approach to diet and health.Currently based at King's College London (KCL), I will work for one year with experts at the University of Southampton who will be providing training in the different statistical methods needed to do this work and I will also attend external training courses. My particular interest is in the relationship between mothers' diet in pregnancy and how this may affect the developing baby in a way that influences the risk of the baby developing obesity in childhood. During this period of training, I will test out the methods learnt using data that are already available from two studies of women and their children in the UK. These have information on diet across pregnancy, infancy and into childhood. They also have measures of 'fatness' in infancy and childhood. The datasets are unique, as they comprise very detailed information about food intake and measures of body fat, and provide an excellent training resource. A unique element of this work is that we also have biological measures of nutritional health evaluated in the blood of the women from one of the studies, taken at different times in pregnancy. This will add an extra level of detail and help me to work out how diet in the mother may directly affect the developing baby, to increase or reduce the risk of obesity in the child. This project is the first of its kind within nutritional sciences and has potential to pave the way for new and innovative analytical techniques within the field. In addition, it will provide results that could translate into public health policies focused on maternal diet and the burden of childhood obesity.

目前，当科学家分析饮食数据时，他们寻找某个时间点的饮食摄入量与当时的健康状况或晚年健康状况之间的关系。虽然这可能是有用的，并且是一种为许多与营养相关的公共卫生战略提供信息的方法，但统计科学的最新发展应该有助于提供更深入的见解，通过查看随着时间的推移对饮食数据的重复测量。这个奖项的目的是为这种创新的饮食和健康方法开发方法。目前在伦敦国王学院（KCL）工作，我将与南安普顿大学的专家一起工作一年，他们将提供不同的统计方法的培训，我也将参加外部培训课程。我特别感兴趣的是母亲在怀孕期间的饮食之间的关系，以及这可能如何影响发育中的婴儿，从而影响婴儿在儿童时期患肥胖症的风险。在这段培训期间，我将使用英国两项妇女及其子女研究中已有的数据来测试所学到的方法。这些有关于怀孕、婴儿期和儿童期饮食的信息。他们也有婴儿期和儿童期的“肥胖”指标。这些数据集是独一无二的，因为它们包含有关食物摄入和身体脂肪测量的非常详细的信息，并提供了极好的培训资源。这项工作的一个独特之处在于，我们还对其中一项研究中的妇女在怀孕期间的不同时间进行了血液营养健康的生物测量。这将增加一个额外的细节水平，并帮助我弄清楚母亲的饮食如何直接影响发育中的婴儿，增加或减少儿童肥胖的风险。该项目是营养科学领域的第一个此类项目，有可能为该领域的新的创新分析技术铺平道路。此外，它将提供的结果可以转化为关注孕产妇饮食和儿童肥胖负担的公共卫生政策。

项目成果

Evaluation and interpretation of latent class modelling strategies to characterise dietary trajectories across early life: a longitudinal study from the Southampton Women's Survey.

• DOI: 10.1017/s000711452200263x
• 发表时间: 2023-06-14
• 期刊: BRITISH JOURNAL OF NUTRITION
• 影响因子: 3.6
• 作者: Dalrymple, Kathryn V.;Vogel, Christina;Godfrey, Keith M.;Baird, Janis;Hanson, Mark A.;Cooper, Cyrus;Inskip, Hazel M.;Crozier, Sarah R.
• 通讯作者: Crozier, Sarah R.

Project20: maternity care mechanisms that improve access and engagement for women with social risk factors in the UK - a mixed-methods, realist evaluation.

• DOI: 10.1136/bmjopen-2022-064291
• 发表时间: 2023-02-07
• 期刊: BMJ open
• 影响因子: 2.9

Longitudinal dietary trajectories from preconception to mid-childhood in women and children in the Southampton Women's Survey and their relation to offspring adiposity: a group-based trajectory modelling approach.

• DOI: 10.1038/s41366-021-01047-2
• 发表时间: 2022-04
• 期刊: International journal of obesity (2005)
• 作者: Dalrymple KV;Vogel C;Godfrey KM;Baird J;Harvey NC;Hanson MA;Cooper C;Inskip HM;Crozier SR
• 通讯作者: Crozier SR

Micronutrient supplementation interventions in preconception and pregnant women at increased risk of developing pre-eclampsia: a systematic review and meta-analysis.

在先入后和孕妇中的微量营养素补充干预措施增加了前宾夕法尼亚前的风险：系统的审查和荟萃分析。

• DOI: 10.1038/s41430-022-01232-0
• 发表时间: 2023-07
• 期刊: European journal of clinical nutrition
• 影响因子: 4.7

Longitudinal dietary trajectories from pregnancy to 3 years post delivery in women with obesity: relationships with adiposity.

肥胖女性从怀孕到产后 3 年的纵向饮食轨迹：与肥胖的关系。

• DOI: 10.1002/oby.23706
• 发表时间: 2023
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Dalrymple KV