CoEN5020 Advancing adaptive deep brain stimulation for gait disturbances and freezing of gait in Parkinson's disease

CoEN5020 推进适应性深部脑刺激治疗帕金森病的步态障碍和冻结步态

• 批准号: MR/V00655X/1
• 负责人: Huiling Tan
• 金额: $ 30.57万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV00655X%2F1
• 关键词: CoEN5020; Advancing; adaptive; deep; brain

Freezing of Gait (FoG) is characterized by sudden motor blocks during walking, and can occur with a wide variety of triggers such as extra cognitive load or during turning. This is a devastating symptom of Parkinson's disease (PD) effecting more than half of all patients. Associated with an increased risk of falls, fall-related injuries and mortality, it poses a major burden to patients and their families. Despite its significant health and socioeconomic impacts, FoG still represents a major therapeutic challenge in PD, as it is often unresponsive to dopaminergic medication or conventional continuous deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus internus (GPi). Inthis proposal, we aim to better understand the neural basis of FoG in PD with the aim to predict the likely occurrence of these transient FoG episodes, and to evaluate the effectiveness a novel biomimetic pattern of STN stimulation as a treatment promoting resistance to FoG. This would pave the way for early detection of episodic gait disturbances such as the onset of FoG that could be used to control switching between DBS stimulation patterns that are most appropriate for minimizing risk of falling at a given moment in time.

步态冻结（FoG）的特征是在行走过程中突然发生运动阻滞，并且可以在各种触发因素下发生，例如额外的认知负荷或转弯过程中。这是帕金森病（PD）的一种毁灭性症状，影响超过一半的患者。与增加的福尔斯、跌倒相关损伤和死亡风险相关，它给患者及其家庭带来了重大负担。尽管FoG具有显著的健康和社会经济影响，但FoG仍然是PD的主要治疗挑战，因为它通常对多巴胺能药物或丘脑底核（subthalamic nucleus，DBS）或苍白球（globus pallidus internus，GPi）的常规连续脑深部刺激（DBS）无反应。在这个提议中，我们的目标是更好地了解PD中FoG的神经基础，目的是预测这些短暂FoG发作的可能发生，并评估一种新的仿生刺激模式作为促进对FoG抵抗的治疗的有效性。这将为早期检测间歇性步态障碍（例如FoG的发作）铺平道路，FoG可用于控制DBS刺激模式之间的切换，DBS刺激模式最适合于最大限度地降低在给定时刻跌倒的风险。

项目成果

Closed-Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials.

• DOI: 10.1002/mds.28513
• 发表时间: 2021-04
• 期刊: Movement disorders : official journal of the Movement Disorder Society
• 作者: He S;Baig F;Mostofi A;Pogosyan A;Debarros J;Green AL;Aziz TZ;Pereira E;Brown P;Tan H
• 通讯作者: Tan H

Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus

步态相位调节脚桥核中的α和β振荡

• DOI: 10.1101/2021.03.05.434086
• 发表时间: 2021
• 作者: He S

Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation

运动减慢的临床神经生理学询问：调整适应性深部脑刺激的关键一步

• DOI: 10.1016/j.clinph.2023.04.0131388-2457
• 发表时间: 2023
• 期刊: CLINICAL NEUROPHYSIOLOGY
• 影响因子: 4.7
• 作者: Alva Laura

Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus.

• DOI: 10.1523/jneurosci.0770-21.2021
• 发表时间: 2021-10-06
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: He S;Deli A;Fischer P;Wiest C;Huang Y;Martin S;Khawaldeh S;Aziz TZ;Green AL;Brown P;Tan H
• 通讯作者: Tan H

Mechanisms of Network Interactions for Flexible Cortico-Basal Ganglia-Mediated Action Control

灵活皮质基底节介导的动作控制的网络交互机制

• DOI: 10.20944/preprints202103.0478.v1
• 发表时间: 2021
• 作者: Fischer P