Interfacing with the brain for therapy

与大脑连接进行治疗

• 批准号: MC_UU_00003/2
• 负责人: Huiling Tan
• 金额: $ 300.84万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00003%2F2
• 关键词: Interfacing; brain; therapy

The treatment of diseases of the brain remains a major challenge. This is partly because drugs ignore the moment-to-moment interactions between nerve cells that determine brain function and dysfunction. Electrical stimulation therapies, however, can intervene fast enough to modify these interactions. Our central hypothesis is that we can improve therapies based on electrical stimulation by titrating stimulation according to the state of neural circuits at any given instance. In this research programme we will focus on patients with two exemplar conditions, Parkinson’s disease and Essential Tremor, and develop feedback controlled forms of deep brain stimulation, and of non-invasive stimulation techniques where stimulation is delivered by electrodes on the skin to the surface of the brain or to nerves in the limbs. Using these approaches we seek to develop treatment approaches that serve to increase efficacy and lessen side-effects.

脑部疾病的治疗仍然是一个重大挑战。这部分是因为药物忽略了决定大脑功能和功能障碍的神经细胞之间的即时相互作用。然而，电刺激疗法可以足够快地干预以改变这些相互作用。我们的中心假设是，我们可以根据任何给定情况下神经回路的状态通过滴定刺激来改善基于电刺激的治疗。在这项研究计划中，我们将专注于两种典型疾病的患者，帕金森病和原发性震颤，并开发反馈控制形式的深部脑刺激，以及非侵入性刺激技术，其中刺激通过皮肤上的电极传递到大脑表面或四肢神经。使用这些方法，我们寻求开发有助于提高疗效和减少副作用的治疗方法。

项目成果

Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo.

帕金森氏病揭示了丘脑核神经元对体内β-频率皮质输入的潜在灵敏度。

• DOI: 10.1016/j.nbd.2020.105119
• 发表时间: 2020-12
• 期刊: Neurobiology of disease
• 影响因子: 6.1
• 作者: Baaske MK;Kormann E;Holt AB;Gulberti A;McNamara CG;Pötter-Nerger M;Westphal M;Engel AK;Hamel W;Brown P;Moll CKE;Sharott A
• 通讯作者: Sharott A

Entraining Stepping Movements of Parkinson's Patients to Alternating Subthalamic Nucleus Deep Brain Stimulation.

• DOI: 10.1523/jneurosci.1767-20.2020
• 发表时间: 2020-11-11
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Fischer P;He S;de Roquemaurel A;Akram H;Foltynie T;Limousin P;Zrinzo L;Hyam J;Cagnan H;Brown P;Tan H
• 通讯作者: Tan H

Entraining stepping movements of Parkinson's patients to alternating subthalamic nucleus deep brain stimulation

交替丘脑底核深部脑电刺激帕金森病患者的步进运动

• DOI: 10.1101/2020.08.16.253062
• 发表时间: 2020
• 作者: Fischer P

Mechanisms of Network Interactions for Flexible Cortico-Basal Ganglia-Mediated Action Control

灵活皮质基底节介导的动作控制的网络交互机制

• DOI: 10.20944/preprints202103.0478.v1
• 发表时间: 2021
• 作者: Fischer P

Tailoring Human Sleep: selective alteration through Brainstem Arousal Circuit Stimulation

定制人类睡眠：通过脑干唤醒回路刺激进行选择性改变

• DOI: 10.1101/2023.01.18.23284688
• 发表时间: 2023
• 作者: Deli A