BIOMECHANICS OF MICRO BLOOD VESSELS AND MICROCIRCULATION

微血管和微循环的生物力学

• 批准号: 6110023
• 负责人: YUAN-CHENG FUNG
• 金额: $ 15.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6110023
• 关键词: angiogenesis; biomechanics; biomedical automation; blood pressure; capillary; diabetes mellitus; elastin; hypertension; laboratory rat; lung; mathematical model; mesentery; microcirculation; temperature; tissue /cell culture; vascular endothelium; vascular smooth muscle; vasomotion

The objective of this research is to gain a better understanding of the dynamic role played by stress and strain on the remodeling and growth of the blood vessels. When blood pressure or flow is increased above the normal, changes occur in the blood vessel lumen, wall thickness, zero- stress state, fine structure of the intima, media and adventitia layers, geometry and dimensions of the endothelial and smooth muscle cells, the mechanical properties of the intima-media and adventitial layers, capillaries, and even branching patterns and total generation numbers. Hence our HYPOTHESIS: Stress and strain are important factors that determine blood vessel structure and function, together with chemical factors. We want to document their influence mathematically, with the following SPECIFIC AIMS: 1) To determine the effects of changing blood shear and blood pressure on the remodeling of the blood vessels and express them in the form of indicial functions. 2) To obtain data on the morphology, histology and experimental mechanics of vessels and use them to calculate the stress and strain distribution and determine the strain energy functions of the intima-media and adventitia layers which change in the remodeling process. 3) To demonstrate the applications of the results by solving some key problems of the heart. The biology of growth and remodeling should be studied at all levels from atoms to the whole animal. The scale of the level chosen for the present study is that of the tissue with a minimum dimension in the mu-m range. In this length scale, our RATIONALE is that the engineering approach is the most efficient, in which questions in physiology and medicine can be converted to boundary - value problems whose solutions can be tested experimentally. In the process, we correct a current deficiency in biomedical science: people really do not know how to compute stress and strain in the tissues of blood vessels. We will make an effort to give biomechanics a firm foundation.

这项研究的目的是为了更好地了解 应力和应变在细胞重塑和生长中的动态作用 血管。当血压或血流量增加到超过 正常，血管管腔改变，壁厚，零- 应力状态，内膜、中层和外膜层的精细结构， 内皮细胞和平滑肌细胞的几何形状和尺寸， 内膜-中层和外膜的力学性质， 毛细血管，甚至分支模式和总世代数。 因此我们的假设是：应力和应变是 测定血管结构和功能，以及化学物质 各种因素。我们想用数学的方式记录他们的影响， 具体目标如下：1)确定换血的效果 剪切力和血压对血管重塑的影响 用符号函数的形式来表示它们。2)获取关于 血管的形态、组织学和实验力学及其应用 计算应力和应变分布并确定应变 血管内膜-中层和外膜层的能量函数 重塑的过程。3)演示结果的应用 通过解决心脏的一些关键问题。生长和生长的生物学 重塑应该在从原子到整个动物的各个层面上进行研究。 为本研究选择的水平的尺度是组织的尺度 其最小尺寸在Mu-m范围内。在这个长度范围内，我们的 基本原理是工程方法是最有效的，在 生理学和医学中的问题可以转化为边值问题 其解决方案可以通过实验进行测试的问题。在这个过程中，我们 纠正目前生物医学科学中的一个不足：人们真的不 知道如何计算血管组织中的应力和应变。我们 将努力为生物力学奠定坚实的基础。