Ethnicity and COVID-19: investigating the determinants of excess risk in UK Biobank

种族和 COVID-19：调查英国生物银行过度风险的决定因素

• 批准号: MR/V020536/1
• 负责人: Thomas Yates
• 金额: $ 16.19万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV020536%2F1
• 关键词: Ethnicity; COVID; 19; investigating; determinants

What is the problem? People from minority ethnic groups seem to be disproportionally affected by COVID-19, particularly South Asian and Black and African Caribbean communities.What has been done so far? National datasets have shown that minority ethnic groups are up to 4 times more likely to die from COVID-19. However, the reason for this increased risk is not known. What are we going to do?We will use a large dataset, called UK Biobank, which has been linked to national COVID-19 data. Within this dataset, we will use statistical modelling to examine whether the increased risk in minority ethnic groups is explained by differences in underlying health status, lifestyle behaviours such as physical activity, and environmental factors such as air pollution or measures of social inequality.Why is this important?This work will start to unpick why minority ethnic groups may be at increased risk and whether this increased risk is spread equality across the population. For example, is the increased risk explained by a higher burden of other diseases such as heart disease or diabetes or by living in more polluted areas? Do otherwise healthy individuals from minority ethnic groups still have an increased risk? Addressing these question will help inform public health priorities and actions.

有什么问题吗？来自少数民族群体的人似乎受到COVID-19的严重影响，特别是南亚和黑人以及非洲加勒比社区。到目前为止，我们做了什么？国家数据集显示，少数民族群体死于COVID-19的可能性高达4倍。然而，这种风险增加的原因尚不清楚。我们该怎么办？我们将使用一个名为UK Biobank的大型数据集，该数据集已与国家COVID-19数据相关联。在这个数据集中，我们将使用统计模型来研究少数民族群体的风险增加是否可以通过基础健康状况，生活方式行为（如体育活动）和环境因素（如空气污染或社会不平等措施）的差异来解释。这项工作将开始解开为什么少数民族群体可能面临更大的风险，以及这种风险的增加是否会在整个人口中传播平等。例如，增加的风险是否可以解释为心脏病或糖尿病等其他疾病的更高负担，或生活在污染更严重的地区？来自少数民族的健康个体是否仍然有增加的风险？解决这些问题将有助于为公共卫生优先事项和行动提供信息。

项目成果

Remission of type 2 diabetes and improved diastolic function by combining structured exercise with meal replacement and food reintroduction among young adults: the RESET for REMISSION randomised controlled trial protocol.

• DOI: 10.1136/bmjopen-2022-063888
• 发表时间: 2022-09-21
• 期刊: BMJ open
• 影响因子: 2.9

Association between household size and COVID-19: A UK Biobank observational study.

家庭规模与Covid-19之间的关联：英国生物库观察研究。

• DOI: 10.1177/01410768211073923
• 发表时间: 2022-04
• 期刊: Journal of the Royal Society of Medicine
• 影响因子: 17.3
• 作者: Gillies CL;Rowlands AV;Razieh C;Nafilyan V;Chudasama Y;Islam N;Zaccardi F;Ayoubkhani D;Lawson C;Davies MJ;Yates T;Khunti K
• 通讯作者: Khunti K

Patterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the U.K.

• DOI: 10.1186/s12879-021-06600-y
• 发表时间: 2021-09-04
• 期刊: BMC infectious diseases
• 影响因子: 3.7
• 作者: Chudasama YV;Zaccardi F;Gillies CL;Razieh C;Yates T;Kloecker DE;Rowlands AV;Davies MJ;Islam N;Seidu S;Forouhi NG;Khunti K
• 通讯作者: Khunti K

COVID-19 vaccination uptake amongst ethnic minority communities in England: a linked study exploring the drivers of differential vaccination rates.

• DOI: 10.1093/pubmed/fdab400
• 发表时间: 2023-03-14
• 期刊: Journal of public health (Oxford, England)
• 作者: Gaughan CH;Razieh C;Khunti K;Banerjee A;Chudasama YV;Davies MJ;Dolby T;Gillies CL;Lawson C;Mirkes EM;Morgan J;Tingay K;Zaccardi F;Yates T;Nafilyan V
• 通讯作者: Nafilyan V

Ethnic differences in COVID-19 mortality during the first two waves of the Coronavirus Pandemic: a nationwide cohort study of 29 million adults in England.

• DOI: 10.1007/s10654-021-00765-1
• 发表时间: 2021-06
• 期刊: European journal of epidemiology
• 影响因子: 13.6
• 作者: Nafilyan V;Islam N;Mathur R;Ayoubkhani D;Banerjee A;Glickman M;Humberstone B;Diamond I;Khunti K
• 通讯作者: Khunti K