Sedentary behaviour in older adults: investigating a new therapeutic paradigm

老年人的久坐行为：研究新的治疗范式

• 批准号: MR/K025090/1
• 负责人: Thomas Yates
• 金额: $ 108.7万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK025090%2F1
• 关键词: Sedentary; behaviour; older; adults; investigating

Older age is associated with an increased risk of many diseases, poor physical function and frailty, cognitive decline and other forms of disability. Also, some groups such as South Asians have higher rate of disease. Research has shown that many of these factors are improved by higher levels of physical activity. However, little is known about the role of sedentary behaviour i.e., sitting time in older adults. Some research has started to show that reducing the time that you spend sitting can reduce the risk of many diseases and improve functional health. This research suggests that improvements in health may be gained by simply helping people to swop time spent sitting with time spent standing or in light-intensity walking. Older adults spend around 70% of their day sitting but little is currently known about whether reducing sitting time promotes health and wellbeing in older adults. This may be particularly relevant to older adults where fear of falls, joint pain, decreased physical function and other contraindications may limit motivation and ability to engage in much purposeful exercise. This grant is therefore going to focus on investigating the impact of sitting in older adults. The results of this research will inform larger studies and public health initiatives aimed at reducing sitting time in the future.Our research plan includes three work packages. In work package one, we will develop a method of estimating time spent sitting and in physical activity which hasn't been done before in older adults. This will be done in a laboratory where participants will complete a set of activities and we will measure the intensity of these activities. Another part of this work package is to use existing data that has been collected as part of the Health Survey for England. We will re-analyse this data to investigate how much sitting and physical activity older adults do, when and how often they do these behaviours (e.g., morning ,afternoon, evening, numbers of times in the day and how long for each time), and compare this to other age groups. We will also look at the relationship between sitting and physical activity with health and wellbeing in older adults. This data will be supplemented with data that we have collected within our department in a large population of older multi-ethnic adults. Work package two will develop a novel way of measuring sitting time which allows researchers to capture the location of where older adults spend the their time around the home/car environment and more accurately measure sitting time. This will involve a wrist worn device along with very small tags that can be attached to objects (such as chairs, tables, computers etc). We can then combine the information from both devices to measure time spent sitting but also the type of sitting behaviour and the location around the home (e.g., sofa in living room, computer in office, dining table etc). This will help researchers to develop ways to help people to reduce their sitting time. This novel method will be tested in a laboratory and also a small number of people will be asked to test it in their daily lives. Once they have done this we will ask them for feedback on perceptions of sedentary behaviour and these novel method of measuring sitting. Work package three will be a laboratory study to investigate the impact of sitting down all day (condition one), reducing sitting by standing every 30 minutes for a few minutes (condition two) and reducing sitting by slowly walking every 30 minutes for a few minutes (condition three). Participants will come into the laboratory and perform each of these conditions over a day (8am-5pm). During these conditions blood sugar, insulin, fats in the blood, mood and cognitive function will be measured. This work package will investigate how harmful sitting is for health and whether health can be improved by reducing sitting time either by standing or light walking or both.

老年与许多疾病的风险增加、身体机能差和虚弱、认知能力下降和其他形式的残疾有关。此外，一些群体，如南亚人有较高的发病率。研究表明，这些因素中的许多都可以通过更高水平的身体活动来改善。然而，人们对久坐行为的作用知之甚少，老年人的静坐时间一些研究已经开始表明，减少坐着的时间可以降低许多疾病的风险，改善功能健康。这项研究表明，通过简单地帮助人们将坐着的时间与站着或轻度步行的时间交换，可以改善健康状况。老年人一天中大约70%的时间都是坐着的，但目前对减少坐着的时间是否能促进老年人的健康和福祉知之甚少。这可能与老年人特别相关，其中害怕福尔斯、关节疼痛、身体功能下降和其他禁忌症可能会限制从事有目的运动的动机和能力。因此，这笔赠款将重点调查老年人坐着的影响。这项研究的结果将为未来旨在减少坐着时间的大型研究和公共卫生倡议提供信息。我们的研究计划包括三个工作包。在第一个工作包中，我们将开发一种方法来估计花费在坐着和身体活动上的时间，这在老年人中还没有做过。这将在实验室中进行，参与者将完成一系列活动，我们将测量这些活动的强度。该工作包的另一部分是使用作为英格兰健康调查一部分收集的现有数据。我们将重新分析这些数据，以调查老年人做多少坐姿和身体活动，他们何时以及多久做这些行为（例如，上午，下午，晚上，一天中的次数和每次的时间），并将其与其他年龄组进行比较。我们还将研究坐着和身体活动与老年人健康和福祉之间的关系。这些数据将补充我们在我们部门内收集的大量老年多种族成年人的数据。第二个工作包将开发一种测量坐着时间的新方法，使研究人员能够捕捉老年人在家庭/汽车环境中花费时间的位置，并更准确地测量坐着时间。这将涉及一个手腕佩戴设备沿着与非常小的标签，可以附加到物体（如椅子，桌子，电脑等）。然后，我们可以将来自两个设备的信息联合收割机组合起来，以测量坐着的时间，以及坐着行为的类型和家周围的位置（例如，客厅沙发，办公室电脑，餐桌等）。这将有助于研究人员开发帮助人们减少坐着时间的方法。这种新方法将在实验室进行测试，也将要求少数人在日常生活中进行测试。一旦他们这样做了，我们将要求他们对久坐行为的看法和这些新的测量坐姿的方法提供反馈。工作包三将是一项实验室研究，以调查整天坐着的影响（条件一），通过每30分钟站立几分钟来减少坐着（条件二），并通过每30分钟缓慢步行几分钟来减少坐着（条件三）。参与者将进入实验室，并在一天内（上午8点至下午5点）执行这些条件。在这些条件下，血糖，胰岛素，血液中的脂肪，情绪和认知功能将被测量。这个工作包将调查坐着对健康的危害，以及是否可以通过站立或轻走或两者兼而有之来减少坐着的时间来改善健康。

项目成果

Additional file 1: Figure S1. of Associations of mutually exclusive categories of physical activity and sedentary time with markers of cardiometabolic health in English adults: a cross-sectional analysis of the Health Survey for England

附加文件 1：图 S1。

• DOI: 10.6084/m9.figshare.c.3610589_d1
• 发表时间: 2016
• 作者: Bakrania K

A Novel Algorithm for Determining the Contextual Characteristics of Movement Behaviors by Combining Accelerometer Features and Wireless Beacons: Development and Implementation.

• DOI: 10.2196/mhealth.8516
• 发表时间: 2018-04-20
• 期刊: JMIR mHealth and uHealth
• 影响因子: 5
• 作者: Magistro D;Sessa S;Kingsnorth AP;Loveday A;Simeone A;Zecca M;Esliger DW
• 通讯作者: Esliger DW

FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.

• DOI: 10.1136/bmj.i4707
• 发表时间: 2016-09-20
• 期刊: BMJ (Clinical research ed.)
• 作者: Livingstone KM;Celis-Morales C;Papandonatos GD;Erar B;Florez JC;Jablonski KA;Razquin C;Marti A;Heianza Y;Huang T;Sacks FM;Svendstrup M;Sui X;Church TS;Jääskeläinen T;Lindström J;Tuomilehto J;Uusitupa M;Rankinen T;Saris WH;Hansen T;Pedersen O;Astrup A;Sørensen TI;Qi L;Bray GA;Martinez-Gonzalez MA;Martinez JA;Franks PW;McCaffery JM;Lara J;Mathers JC
• 通讯作者: Mathers JC

A Novel Algorithm for Determining the Contextual Characteristics of Movement Behaviors by Combining Accelerometer Features and Wireless Beacons: Development and Implementation

通过结合加速度计功能和无线信标来确定运动行为的上下文特征的新算法：开发和实现

• DOI: 10.2196/preprints.8516
• 发表时间: 2017
• 作者: Magistro D

Associations of mutually exclusive categories of physical activity and sedentary time with markers of cardiometabolic health in English adults: a cross-sectional analysis of the Health Survey for England.

• DOI: 10.1186/s12889-016-2694-9
• 发表时间: 2016-01-12
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Bakrania K;Edwardson CL;Bodicoat DH;Esliger DW;Gill JM;Kazi A;Velayudhan L;Sinclair AJ;Sattar N;Biddle SJ;Khunti K;Davies M;Yates T
• 通讯作者: Yates T