ANATOMICAL BASIS OF LANGUAGE

这个项目的总体目标仍然是描绘神经系统。 潜在的语言，通过在患者身上进行的特殊实验 伴有局灶性脑损伤。第一个具体目标是映射神经基础 词汇库的。这些研究主要集中在词汇支持系统上 通路，我们假设它是基于左侧的颞叶皮质。这个 第二个具体目标与视觉运动语言的加工有关 手语，如美国手语(ASL)中使用的手语。我们会 研究表示和访问这些信息所需的神经系统 听力障碍患者ASL词汇习得的体征研究 左半球和右半球广泛的局灶性损伤。此外，我们还将 继续评估传统诊断类别的临床价值 通过研究失语症的解剖-临床一致性 在我们的数据库中的相关性，并研究听觉的神经基础 感知力。 这一结果将有助于更精确地描述神经 在语言的基础上，在系统一级，特别是进一步 有关神经和认知体系结构的规范 词汇通达和词汇表征。这一结果将有助于揭示 失语症的诊断和生理病理，并协助 制定计划以恢复大量中风和头部 出现语言障碍的伤害受害者。我们的方法充分利用了 对成年人类的研究提供了独特的机会 局灶性脑损伤，并寻求在两个方面提高语言知识 神经和心理层面。

The overall goal of this project remains the delineation of neural systems underlying language, by means of special experiments conducted in patients with focal brain damage. The first specific aim is to map the neural basis of the lexicon. The studies focus on the systems supporting lexical access, which we hypothesize to be based on left temporal cortices. The second specific aim relates to the processing of visuomotor linguistic signs, such as those used in American Sign Language (ASL). We will investigate the neural systems required for representing and accessing such signs, by studying the acquisition of ASL lexicon in hearing patients with a wide range of focal damage in left and right hemispheres. Also, we will continue to assess the clinical value of traditional diagnostic categories of aphasia, by investigating the consistency of anatomo-clinical correlations in our database, and to study the neural basis of auditory perception. The results will contribute to a more precise formulation of the neural basis of language, at systems level, and in particular, to further specification of the neural and cognitive architectures pertaining to lexical access and lexical representation. The results will shed light on the diagnosis and physiopathology of the aphasias, and assist in the development of programs to rehabilitate the large number of stroke and head injury victims who develop language impairments. Our approach capitalizes on the unique opportunities afforded by the study of adult humans with focal brain injury, and seeks to advance knowledge of language at both the neural and psychological levels.