临床前和临床药理学/实验治疗-猫眼课题宝

临床前和临床药理学/实验治疗

批准号：

6123698

负责人：

J GREM

金额：

$0.0万

依托单位：

DIVISION OF CLINICAL SCIENCES - NCI

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/6123698

关键词：

adenocarcinoma antineoplastics camptothecin clinical research clinical trial phase I colorectal neoplasms dosage drug administration rate /duration drug screening /evaluation fluorouracil gastrointestinal neoplasms human subject human therapy evaluation neoplasm /cancer chemotherapy neoplasm /cancer genetics neoplasm /cancer pharmacology pharmacokinetics tissue /cell culture

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英文摘要

"Innovative strategies are needed to improve the prognosis of patients with adenocarcinomas arising in the gastrointestinal tract. We are studying the interaction of modulatory & cytotoxic agents with fluorouracil in vitro to define optimal sequences for potential clinical use. Studies are designed to elucidate the optimal schedule of administration & mechanism of action of novel agents with activity against colon cancer cell lines to facilitate their rational clinical use. We implement clinical trials that incorporate clinical pharmacokinetic, biochemical &/or molecular endpoints. New analytic assay methods are developed to measure the pharmacokinetics & intracellular pharmacodynamics of the anticancer agents. Our goal is to develop new agents & drug combinations for patients with GI cancers, & to develop strategies that selectively target cancer cells with genomic instability &/or impaired programmed cell death pathways."

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