PHOSP-COVID Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes

PHOSP-COVID 住院后 COVID-19 研究：了解和改善长期健康结果的国家联盟

• 批准号: MR/V027859/1
• 负责人: Christopher Brightling
• 金额: $ 1135.86万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV027859%2F1
• 关键词: PHOSP; COVID; Post; hospitalisation; 19

The COVID-19 pandemic has tragically led to severe acute illness, hospitalisation and death. Beyond the health of those affected, it has had widespread economic, psychological and societal effects. The clinical spectrum is broad, ranging from those with no or minimal symptoms to severe pneumonia in 15-20% with evidence of widespread disease beyond the lung. As we emerge from the first wave of the pandemic we have new insights into the acute phase of this disease but very little information concerning longterm effects of COVID-19 and the ongoing medical, psychological and rehabilitation needs of these patients. We shall establish a national consortium and a research platform embedded within clinical care to understand and improve long-term outcomes for survivors following hospitalisation with COVID-19. We have built the consortium from existing expert groups across the UK and shall use standardised assessments of patients, including advanced imaging, recording of information and collection of samples. This study will provide us with a comprehensive understanding of the impact on the health of those that have been hospitalised with COVID-19. This will enable trials of new strategies of clinical care including personalised treatments to improve the long-term outcome of current and future COVID-19 survivors.

199年的大流行导致严重的急性疾病，住院和死亡。除了受影响的人的健康之外，它还具有广泛的经济，心理和社会影响。临床光谱广泛，从没有或最少症状的临床范围到15-20％的严重肺炎，肺部广泛疾病的证据以外。当我们从大流行的第一波中出现时，我们对这种疾病的急性阶段有了新的见解，但是关于Covid-19的长期影响以及这些患者持续的医疗，心理和康复需求的信息很少。我们将建立一个国家财团和一个嵌入临床护理中的研究平台，以理解和改善Covid-19的住院后幸存者的长期成果。我们已经从英国现有专家团体建立了财团，并应对患者的标准评估，包括高级成像，记录信息和样本收集。这项研究将使我们对与Covid-19的患者的健康影响有关对健康的影响的影响。这将实现对新的临床护理策略的试验，包括个性化治疗方法，以改善当前和未来的Covid-19幸存者的长期结果。

项目成果

Longitudinal trajectory of cardiac magnetic resonance and cardiopulmonary exercise testing findings in moderate to severe COVID-19 and association with symptoms

中度至重度 COVID-19 心脏磁共振和心肺运动测试结果的纵向轨迹及其与症状的关联

• 发表时间: 2021
• 期刊: EUROPEAN HEART JOURNAL
• 影响因子: 39.3
• 作者: Cassar M. P.

Cohort profile: post-hospitalisation COVID-19 study (PHOSP-COVID)

• DOI: 10.1101/2023.05.08.23289442
• 发表时间: 2023-01-01
• 期刊: PREPRINT
• 作者: Elneima, O.

Impact of ethnicity on the accuracy of measurements of oxygen saturations: A retrospective observational cohort study.

• DOI: 10.1016/j.eclinm.2022.101428
• 发表时间: 2022-06
• 期刊: EClinicalMedicine
• 影响因子: 15.1

Symptom Persistence Despite Improvement in Cardiopulmonary Health - Insights from longitudinal CMR, CPET and lung function testing post-COVID-19.

• DOI: 10.1016/j.eclinm.2021.101159
• 发表时间: 2021-11
• 期刊: EClinicalMedicine
• 影响因子: 15.1
• 作者: Cassar MP;Tunnicliffe EM;Petousi N;Lewandowski AJ;Xie C;Mahmod M;Samat AHA;Evans RA;Brightling CE;Ho LP;Piechnik SK;Talbot NP;Holdsworth D;Ferreira VM;Neubauer S;Raman B
• 通讯作者: Raman B

The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium.

• DOI: 10.1186/s13063-023-07093-7
• 发表时间: 2023-01-26
• 期刊: TRIALS
• 影响因子: 2.5
• 作者: Daynes, Enya;Baldwin, Molly;Greening, Neil J.;Yates, Thomas;Bishop, Nicolette C.;Mills, George;Roberts, Matthew;Hamrouni, Malik;Plekhanova, Tatiana;Vogiatzis, Ioannis;Echevarria, Carlos;Nathu, Rashmita;McAuley, Hamish J. C.;Latimer, Lorna;Glennie, Jennifer;Chambers, Francesca;Penfold, Ruth;Hume, Emily;Magaritis, Dimitrios;Alexiou, Charikleia;Potthoff, Sebastian;Hogg, Mitchell James;Haighton, Catherine;Nichol, Bethany;Leavy, Olivia C.;Richardson, Matthew;Elneima, Omer;Singapuri, Amisha;Sereno, Marco;Saunders, Ruth M.;Harris, Victoria C.;Nolan, Claire M.;Bolton, Charlotte;Houchen-Wolloff, Linzy;Harrison, Ewen M.;Lone, Nazir;Quint, Jennifer;Chalmers, James D.;Ho, Ling-Pei;Horsley, Alex;Marks, Michael;Poinasamy, Krisnah;Ramen, Betty;Wain, Louise V.;Brightling, Christopher;Man, William D. -C.;Evans, Rachael;Singh, Sally J.
• 通讯作者: Singh, Sally J.