PHOSP-COVID Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes

PHOSP-COVID 住院后 COVID-19 研究：了解和改善长期健康结果的国家联盟

• 批准号: MR/V027859/1
• 负责人: Christopher Brightling
• 金额: $ 1135.86万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV027859%2F1
• 关键词: PHOSP; COVID; Post; hospitalisation; 19

The COVID-19 pandemic has tragically led to severe acute illness, hospitalisation and death. Beyond the health of those affected, it has had widespread economic, psychological and societal effects. The clinical spectrum is broad, ranging from those with no or minimal symptoms to severe pneumonia in 15-20% with evidence of widespread disease beyond the lung. As we emerge from the first wave of the pandemic we have new insights into the acute phase of this disease but very little information concerning longterm effects of COVID-19 and the ongoing medical, psychological and rehabilitation needs of these patients. We shall establish a national consortium and a research platform embedded within clinical care to understand and improve long-term outcomes for survivors following hospitalisation with COVID-19. We have built the consortium from existing expert groups across the UK and shall use standardised assessments of patients, including advanced imaging, recording of information and collection of samples. This study will provide us with a comprehensive understanding of the impact on the health of those that have been hospitalised with COVID-19. This will enable trials of new strategies of clinical care including personalised treatments to improve the long-term outcome of current and future COVID-19 survivors.

不幸的是，COVID-19大流行导致了严重的急性疾病、住院和死亡。除了受影响者的健康之外，它还产生了广泛的经济、心理和社会影响。临床范围很广，从无症状或轻微症状到15-20%的严重肺炎，并有证据表明肺部以外的广泛疾病。随着我们走出大流行的第一波，我们对这种疾病的急性期有了新的认识，但关于COVID-19的长期影响以及这些患者持续的医疗、心理和康复需求的信息却很少。我们将建立一个国家联盟和一个嵌入临床护理的研究平台，以了解和改善COVID-19住院后幸存者的长期结果。我们已经从英国现有的专家组中建立了联盟，并将对患者进行标准化评估，包括先进的成像、信息记录和样本收集。这项研究将使我们全面了解COVID-19对住院患者健康的影响。这将有助于试验包括个性化治疗在内的临床护理新战略，以改善当前和未来COVID-19幸存者的长期预后。

项目成果

Impact of ethnicity on the accuracy of measurements of oxygen saturations: A retrospective observational cohort study.

• DOI: 10.1016/j.eclinm.2022.101428
• 发表时间: 2022-06
• 期刊: EClinicalMedicine
• 影响因子: 15.1

Longitudinal trajectory of cardiac magnetic resonance and cardiopulmonary exercise testing findings in moderate to severe COVID-19 and association with symptoms

中度至重度 COVID-19 心脏磁共振和心肺运动测试结果的纵向轨迹及其与症状的关联

• 发表时间: 2021
• 期刊: EUROPEAN HEART JOURNAL
• 影响因子: 39.3
• 作者: Cassar M. P.

The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium.

Covid-19与Covid-19（PHOSP-R）住院后持续症状的康复作用：代表PHOSP财团的随机平行组对照试验的方案。

• DOI: 10.1186/s13063-023-07093-7
• 发表时间: 2023-01-26
• 期刊: TRIALS
• 影响因子: 2.5
• 作者: Daynes, Enya;Baldwin, Molly;Greening, Neil J.;Yates, Thomas;Bishop, Nicolette C.;Mills, George;Roberts, Matthew;Hamrouni, Malik;Plekhanova, Tatiana;Vogiatzis, Ioannis;Echevarria, Carlos;Nathu, Rashmita;McAuley, Hamish J. C.;Latimer, Lorna;Glennie, Jennifer;Chambers, Francesca;Penfold, Ruth;Hume, Emily;Magaritis, Dimitrios;Alexiou, Charikleia;Potthoff, Sebastian;Hogg, Mitchell James;Haighton, Catherine;Nichol, Bethany;Leavy, Olivia C.;Richardson, Matthew;Elneima, Omer;Singapuri, Amisha;Sereno, Marco;Saunders, Ruth M.;Harris, Victoria C.;Nolan, Claire M.;Bolton, Charlotte;Houchen-Wolloff, Linzy;Harrison, Ewen M.;Lone, Nazir;Quint, Jennifer;Chalmers, James D.;Ho, Ling-Pei;Horsley, Alex;Marks, Michael;Poinasamy, Krisnah;Ramen, Betty;Wain, Louise V.;Brightling, Christopher;Man, William D. -C.;Evans, Rachael;Singh, Sally J.
• 通讯作者: Singh, Sally J.

Symptom Persistence Despite Improvement in Cardiopulmonary Health - Insights from longitudinal CMR, CPET and lung function testing post-COVID-19.

症状持续性，尽管心肺健康有所改善 - 纵向CMR，CPET和肺功能测试的见解。

• DOI: 10.1016/j.eclinm.2021.101159
• 发表时间: 2021-11
• 期刊: EClinicalMedicine
• 影响因子: 15.1
• 作者: Cassar MP;Tunnicliffe EM;Petousi N;Lewandowski AJ;Xie C;Mahmod M;Samat AHA;Evans RA;Brightling CE;Ho LP;Piechnik SK;Talbot NP;Holdsworth D;Ferreira VM;Neubauer S;Raman B
• 通讯作者: Raman B

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

• DOI: 10.1016/s2213-2600(21)00286-1
• 发表时间: 2021-12
• 期刊: The Lancet. Respiratory medicine
• 作者: Adeloye D;Elneima O;Daines L;Poinasamy K;Quint JK;Walker S;Brightling CE;Siddiqui S;Hurst JR;Chalmers JD;Pfeffer PE;Novotny P;Drake TM;Heaney LG;Rudan I;Sheikh A;De Soyza A;International COVID-19 Airways Diseases Group
• 通讯作者: International COVID-19 Airways Diseases Group