CORE--CYCLOTRON/ RADIOCHEMISTRY

核心--回旋加速器/放射化学

• 批准号: 6204998
• 负责人: MICHAEL R KILBOURN
• 金额: $ 10.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6204998
• 关键词: biomedical equipment resource; biomedical facility; carbon; chemical synthesis; clinical biomedical equipment; fluorine; iodine; online computer; particle accelerators; positron emission tomography; raclopride; radiochemistry; radionuclides; radiopharmacology; radiotracer; salicylate; tetrabenazine

The Cyclotron/Radiochemistry Core provides all of the radionuclides, radioactive precursors, and approved PET radiopharmaceuticals for the research and clinical projects of this Program Grant. This includes production of fluorine-18 and carbon-11 precursors for Project 1, and routine deliveries of (11C]flumazenil, [11C]N-methylpiperidylbenzilate, [11C]raclopride, [11C]methoxytetrabenazine and 5-[123I]iodobenzovesamicol for Projects 2-4. PET radionuclide production is done using a dedicated Cyclotron Corp. CS-30 cyclotron, outfitted with 10 cyclotron targets, 8 of which are located on a vertical beam ladder. Primary and secondary production targets are available for all radionuclides. All cyclotron targetry, mechanical, electrical and computer systems have been constructed in house; the Core provides all routine and emergency repairs for all of these systems, as well as for the cyclotron itself. Radiochemical research and routine production of PET radiopharmaceuticals is done in a well-equipped radiochemistry laboratory, which has the capability to deliver clinical doses of carbon-11 radiopharmaceuticals in sequential fashion at less than 1 hour intervals. All syntheses are done remotely using apparatus designed, constructed and maintained by Core staff members. The Core provides established expertise in radiochemistry, radiation safety, quality control, and documentation for regulatory approvals.

回旋子/放射化学核心提供所有放射性核素， 放射性前体和批准的宠物放射性药物 该计划赠款的研究和临床项目。这包括 生产项目1的氟-18和碳11前体，以及 （11C]氟马西尼，[11C] N-甲基哌啶基苯甲酸盐的常规递送， [11c] raclopride，[11c]甲氧基苯甲嗪和5- [123i] iodobenzovesamicol 对于项目2-4。 PET放射性核素的产生是使用专用的 Cyclotron Corp. CS-30 Cyclotron，配备10个回旋靶标，其中8个 位于垂直梁梯子上。初级和次要 生产目标可用于所有放射性核素。所有回旋子 目标，机械，电气和计算机系统已经 在房子里建造；核心提供所有常规和紧急维修 对于所有这些系统，以及转基因本身。 宠物放射性药物的放光研究和常规生产 是在设备齐全的放射化学实验室中完成的，该实验室具有 能够输送临床剂量的碳11放射性药物 在不到1小时的时间内进行顺序时尚。所有合成都完成了 使用由核心设计，构造和维护的设备远程使用 工作人员。 核心提供了既定的放射化学专业知识， 辐射安全性，质量控制和监管文件 批准。