CORE--CYCLOTRON/ RADIOCHEMISTRY

核心--回旋加速器/放射化学

• 批准号: 6112129
• 负责人: MICHAEL R KILBOURN
• 金额: --
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6112129
• 关键词: biomedical equipment resource; biomedical facility; carbon; chemical synthesis; clinical biomedical equipment; fluorine; iodine; online computer; particle accelerators; positron emission tomography; raclopride; radiochemistry; radionuclides; radiopharmacology; radiotracer; salicylate; tetrabenazine

The Cyclotron/Radiochemistry Core provides all of the radionuclides, radioactive precursors, and approved PET radiopharmaceuticals for the research and clinical projects of this Program Grant. This includes production of fluorine-18 and carbon-11 precursors for Project 1, and routine deliveries of (11C]flumazenil, [11C]N-methylpiperidylbenzilate, [11C]raclopride, [11C]methoxytetrabenazine and 5-[123I]iodobenzovesamicol for Projects 2-4. PET radionuclide production is done using a dedicated Cyclotron Corp. CS-30 cyclotron, outfitted with 10 cyclotron targets, 8 of which are located on a vertical beam ladder. Primary and secondary production targets are available for all radionuclides. All cyclotron targetry, mechanical, electrical and computer systems have been constructed in house; the Core provides all routine and emergency repairs for all of these systems, as well as for the cyclotron itself. Radiochemical research and routine production of PET radiopharmaceuticals is done in a well-equipped radiochemistry laboratory, which has the capability to deliver clinical doses of carbon-11 radiopharmaceuticals in sequential fashion at less than 1 hour intervals. All syntheses are done remotely using apparatus designed, constructed and maintained by Core staff members. The Core provides established expertise in radiochemistry, radiation safety, quality control, and documentation for regulatory approvals.

回旋加速器/放射化学核心提供所有放射性核素， 放射性前体和批准的 PET 放射性药物 该计划资助的研究和临床项目。这包括 项目1的氟18和碳11前体的生产，以及 常规递送 (11C]氟马西尼、[11C]N-甲基哌啶基苯磺酸盐、 [11C]雷氯必利、[11C]甲氧基丁苯那嗪和5-[123I]碘苯并维沙米考 对于项目 2-4。 PET 放射性核素的生产是使用专用的 Cyclotron Corp. CS-30 回旋加速器，配备 10 个回旋加速器目标，其中 8 个 它们位于垂直梁梯上。小学和中学 所有放射性核素都有生产目标。全回旋加速器 目标、机械、电气和计算机系统 房屋内建造；核心提供所有常规和紧急维修 对于所有这些系统以及回旋加速器本身。 放射化学研究及PET放射性药物的常规生产 是在设备齐全的放射化学实验室中完成的，该实验室具有 提供临床剂量的碳11放射性药物的能力 连续时尚，间隔少于 1 小时。全部合成完成 远程使用由 Core 设计、建造和维护的设备 工作人员。 核心提供放射化学方面的成熟专业知识， 辐射安全、质量控制和监管文件 批准。