CORE--CYCLOTRON / RADIOCHEMISTRY

核心--回旋加速器/放射化学

• 批准号: 6647811
• 负责人: MICHAEL R KILBOURN
• 金额: $ 10.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6647811
• 关键词: biomedical equipment resource; biomedical facility; carbon; chemical registry /resource; chemical synthesis; clinical biomedical equipment; fluorine; methylphenidate; particle accelerators; positron emission tomography; raclopride; radiochemistry; radionuclides; radiopharmacology; tetrabenazine

The Cyclotron/Radiochemistry Core provides all of the radionuclides, radioactive precursors, and approved PET radiopharmaceuticals for the research and clinical projects of this Program Grant. This includes production of fluorine-18 and carbon-11 precursors for Project 1, and routine deliveries of d-threo-[11C]methylphenidate, [11C]raclopride, (+) [11C]dihydrotetrabenazine, [15O]water and 5- [123i]iodobenzovesacicol for Projects 2-4. PET radionuclide production is done using a dedicated Cyclotron Corp. CS-30 cyclotron, outfitted with 10 cyclotron targets, 8 of which are located on a vertical beam ladder. Primary and secondary production targets are available for all radionuclides. All cyclotron targetry, mechanical, electrical and computer systems have been constructed in house; the Core provides all routine and emergency repairs for all of these systems, as well as for the cyclotron itself. Radiochemical research and routine production of PET radiopharmaceuticals is done in a well-equipped radiochemistry laboratory, which has the capability to delivery clinical doses of carbon- 11 radiopharmaceuticals in sequential fashion at less than 1 hour intervals. All syntheses are done remotely using apparatus designed, constructed and maintained by Core staff members. The Core provides established expertise in radiochemistry, radiation safety, quality control (including sterility and pyrogen testing), and documentation for regulatory approvals.

回旋加速器/放射化学核心为本计划资助的研究和临床项目提供所有放射性核素、放射性前体和批准的PET放射性药物。这包括为项目1生产氟-18和碳-11前体，以及为项目2-4常规交付d-苏型-[11 C]哌甲酯、[11 C]雷氯必利、（+）[11 C]二氢丁苯那嗪、[15 O]水和5- [123 i]碘苯并维沙考。 PET放射性核素的生产是使用专用的回旋加速器公司CS-30回旋加速器，配备了10个回旋加速器的目标，其中8个位于垂直束梯。所有放射性核素都有初级和次级生产目标。所有回旋加速器的靶向、机械、电气和计算机系统都是在内部建造的;核心为所有这些系统以及回旋加速器本身提供所有例行和紧急维修。PET放射性药物的放射化学研究和常规生产是在设备齐全的放射化学实验室中进行的，该实验室有能力以小于1小时的间隔连续输送临床剂量的碳-11放射性药物。所有合成都是使用由核心工作人员设计、建造和维护的设备远程完成的。Core提供放射化学、辐射安全、质量控制（包括无菌性和热原测试）和监管批准文件方面的成熟专业知识。