Inflammation in Covid-19: Exploration of Critical Aspects of Pathogenesis (ICECAP)

目前的冠状病毒大流行正在造成严重的疾病和死亡。2019年严重冠状病毒病（Covid-19）可导致急性肺损伤和器官损伤，通常需要重症监护住院并长时间使用呼吸机。由于这是一种新疾病，病毒引起器官损伤的方式尚不清楚。因此，迫切和至关重要的是，必须描述严重Covid-19的影响，以便迅速为临床管理提供信息并确定新的治疗方法。ICECAP联盟是为应对Covid-19大流行而建立的。通过组建一个由临床医生和科学家组成的专家团队，我们正在研究致命的Covid-19的主要特征。授权的医院尸检为死于Covid-19的人提供了一个独特的机会，可以详细研究整个身体，这在生前是不可能的。通过收集和分析在尸检过程中收集的组织样本，这将获得关于冠状病毒在人体多个器官中存在的关键信息，并更深入地了解人体免疫系统的反应。这使我们能够快速回答重要的临床问题，并帮助快速为Covid-19治疗干预措施的评估和开发提供信息。

The current coronavirus pandemic is causing significant illness and death. Severe coronavirus disease 2019 (Covid-19) leads to acute lung damage and organ injury, often requiring intensive care admission and prolonged periods of time on a ventilator. As this disease is new, the way that the virus causes organ injury is not understood. It is therefore urgent and vital that the effects of severe Covid-19 are described to rapidly inform clinical management and identify new treatment approaches.The ICECAP consortium was established as a rapid response to the Covid-19 pandemic. By assembling a team of expert clinicians and scientists we are studying key features of fatal Covid-19. Authorised hospital post-mortem examinations of those who have died from Covid-19 provides a unique opportunity to study the whole body in a level of detail that is not possible during life. By collecting and analysing tissue samples collected during post-mortem examinations this will yield crucial information on the presence of the coronavirus in multiple organs in the body and also understand in greater depth how the body's immune system is responding. This allows us to rapidly answer important clinical questions and help to rapidly inform the evaluation and development of therapeutic interventions for Covid-19.