Inflammation in Covid-19: Exploration of Critical Aspects of Pathogenesis (ICECAP)

Covid-19 中的炎症：发病机制关键方面的探索 (ICECAP)

• 批准号: MR/V028790/1
• 负责人: Christopher Lucas
• 金额: $ 50.58万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV028790%2F1
• 关键词: Inflammation; Covid; 19; Exploration; Critical

The current coronavirus pandemic is causing significant illness and death. Severe coronavirus disease 2019 (Covid-19) leads to acute lung damage and organ injury, often requiring intensive care admission and prolonged periods of time on a ventilator. As this disease is new, the way that the virus causes organ injury is not understood. It is therefore urgent and vital that the effects of severe Covid-19 are described to rapidly inform clinical management and identify new treatment approaches.The ICECAP consortium was established as a rapid response to the Covid-19 pandemic. By assembling a team of expert clinicians and scientists we are studying key features of fatal Covid-19. Authorised hospital post-mortem examinations of those who have died from Covid-19 provides a unique opportunity to study the whole body in a level of detail that is not possible during life. By collecting and analysing tissue samples collected during post-mortem examinations this will yield crucial information on the presence of the coronavirus in multiple organs in the body and also understand in greater depth how the body's immune system is responding. This allows us to rapidly answer important clinical questions and help to rapidly inform the evaluation and development of therapeutic interventions for Covid-19.

目前的冠状病毒大流行正在造成重大疾病和死亡。严重冠状病毒病2019(新冠肺炎)会导致急性肺损伤和器官损伤，通常需要重症监护入院和长时间使用呼吸机。由于这种疾病是一种新疾病，病毒导致器官损伤的方式尚不清楚。因此，迫切而至关重要的是描述严重新冠肺炎的影响，以迅速为临床管理提供信息并确定新的治疗方法。ICECAP联盟的成立是为了对新冠肺炎大流行做出快速反应。通过组建一个由专业临床医生和科学家组成的团队，我们正在研究致命新冠肺炎的关键特征。对死于新冠肺炎的人进行授权的医院尸检提供了一个独特的机会，可以对整个身体进行一生中不可能达到的详细研究。通过收集和分析尸检期间收集的组织样本，这将提供有关冠状病毒在人体多个器官中存在的关键信息，并更深入地了解人体的免疫系统是如何反应的。这使我们能够快速回答重要的临床问题，并有助于迅速了解新冠肺炎治疗干预措施的评估和发展。

项目成果

Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection.

• DOI: 10.1007/s10753-021-01567-z
• 发表时间: 2022-04
• 期刊: Inflammation
• 影响因子: 5.1
• 作者: McAllister MJ;Kirkwood K;Chuah SC;Thompson EJ;Cartwright JA;Russell CD;Dorward DA;Lucas CD;Ho GT
• 通讯作者: Ho GT

Tissue-Specific Immunopathology in Fatal COVID-19.

• DOI: 10.1164/rccm.202008-3265oc
• 发表时间: 2021-01-15
• 期刊: American journal of respiratory and critical care medicine
• 影响因子: 24.7
• 作者: Dorward DA;Russell CD;Um IH;Elshani M;Armstrong SD;Penrice-Randal R;Millar T;Lerpiniere CEB;Tagliavini G;Hartley CS;Randle NP;Gachanja NN;Potey PMD;Dong X;Anderson AM;Campbell VL;Duguid AJ;Al Qsous W;BouHaidar R;Baillie JK;Dhaliwal K;Wallace WA;Bellamy COC;Prost S;Smith C;Hiscox JA;Harrison DJ;Lucas CD
• 通讯作者: Lucas CD

Post-mortem dissection of COVID-19: a pathogenic role for macrophages?

• DOI: 10.1007/s00134-021-06509-9
• 发表时间: 2021-11
• 期刊: Intensive care medicine
• 影响因子: 38.9
• 作者: Velu PP;Lucas CD;Conway Morris A
• 通讯作者: Conway Morris A

Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes

组织特异性蛋白质组揭示 Covid-19 免疫病理学的机制和阶段

• DOI: 10.2139/ssrn.3854606
• 发表时间: 2021
• 期刊: SSRN Electronic Journal
• 作者: Russell C