SELF INJURIOUS BEHAVIOR DECREASED BY PROGESTIN ANDROGEN AGONIST IN MALE RHESUS

孕激素雄激素激动剂可减少雄性恒河猴的自残行为

• 批准号: 6277369
• 负责人: G G EATON
• 金额: $ 7.42万
• 依托单位: OREGON REGIONAL PRIMATE RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277369
• 关键词: Mammalia; Primates; biological products; endocrine gland /system; hormones; nervous system; psychology; reproductive system

Self-injurious behavior (SIB) presents a serious problem in laboratory macaques that cannot be socially housed for scientific reasons. It is also a serious problem among significant numbers of institutionalized children and adults where it is often associated with different forms of brain dysfunction. In macaques, SIB is associated with conditions of social deprivation during early development. We have experienced limited success in reducing SIB in macaques by enhancing their environment with enrichment devices. Psychotropic drugs also help, but problems are associated with their use. Because sexual and aggressive behavioral problems in men have been treated with drugs containing progestin and androgen profiles, we tested the efficacy of cyproterone acetate (CA) on reducing SIB in 8 singly-housed, adult, male rhesus macaques. The main findings were 1) the frequency of occurrence of SIB, and some other atypical behaviors, were significantly reduced after several weeks of CA treatment; 2) blood levels of testosterone were also significantly reduced, but 3) frequency of masturbation and sperm counts did not drop with the treatment (5-10 mg/kg/wk CA). We concluded that CA is a partially effective, long-term treatment (3 months) for adult male macaques whose behavioral problems include SIB. However, in addition to CA, other interventions are needed to eliminate SIB. The findings suggest that SIB is modulated by progestins or androgens. The ability of CA to reduce SIB, but not the frequency of masturbation or sperm counts, has led to the hypothesis that the androgen-like action is sufficient to maintain sexual behavior, but the progestin-like action decreases aggressive behavior. This may further indicate a separation of the neurophysiological mechanisms that control sexual and aggressive behavior. We conclude that CA would be useful in treatment of SIB, especially when it is desired to maintain reproductive capabilities in the subjects.

自我伤害行为(SIB)是一个严重的问题 实验室猕猴不能作为科学研究的社会住所 理由。它也是一个严重的问题在相当数量的 经常与之联系在一起的机构儿童和成人 有不同形式的大脑功能障碍。在猕猴中，SIB是 与早期的社会剥夺状况有关 发展。我们在减少SIB方面取得的成功有限 通过使用富集器改善猕猴的环境。 精神药物也有帮助，但问题与他们的 使用。因为男性的性行为和攻击性行为问题 接受了含有孕激素和雄激素的药物治疗，我们 检测醋酸环丙孕酮(CA)对8只小鼠降低SIB的效果。 独居成年雄性恒河猴。主要研究结果如下：1) SIB的发生频率，以及其他一些非典型行为， 经过几周的CA治疗后显著降低；2) 血液中的睾酮水平也显著降低，但 手淫频率和精子数量并没有随着年龄的增加而下降 处理(5-10 mg/kg/wk CA)。我们得出结论，CA是一个部分 对成年雄性猕猴进行有效的长期治疗(3个月) 其行为问题包括SIB。然而，除了CA之外， 还需要其他干预措施来消除SIB。研究结果表明， SIB受孕激素或雄激素的调节。CA的能力 为了减少SIB，但不是手淫频率或精子数量， 导致了一种假设，即雄激素样的作用就足够了 以维持性行为，但孕激素样活动减少 攻击性行为。这可能进一步表明 控制性和攻击性的神经生理机制 行为。我们认为CA在SIB的治疗中是有用的， 尤其是在希望维持人类生殖能力的情况下 研究对象。