MALE RHESUS SELF AGGRESSION ANTI ANDROGEN CYPROTERONE ACETATE IMPROVE WELL BEING

自咬在雄性非人类灵长类动物中是一个严重的问题 不能被集体安置 在以下方面取得了有限的成功： 通过以下方法减少单笼雄性恒河猴的自咬 用浓缩装置改善他们的环境。 因为性 男性的攻击性行为问题已经用 抗雄激素药物醋酸环丙孕酮（CA），检测CA的疗效 减少八只单独圈养的成年雄性恒河猴的自我攻击 猕猴 基线行为记录14周，随后 50 mg CA/wk治疗8周，然后100 mg CA/wk治疗4周， 并在治疗停止后再观察4周。 一 采用重复测量方差分析（P = 0.5）进行分析 结果 CA治疗期间的主要发现是（1） 自咬等异常行为的发生频率 显著降低，但未消除;（2）血液中 睾酮显著降低;（3）但 自慰和精子数量没有下降。 结论是，CA 对成年雄性恒河猴是一种部分有效的长期治疗方法 有行为问题的猕猴包括自我毁灭 行动 研究结果表明，自我导向的攻击行为 受睾酮和/或其他因素调节。

Self-biting presents a serious problem in male nonhuman primates that cannot be group-housed. Limited success has been experienced in reducing self-biting in singly-housed male rhesus macaques by enhancing their environment with enrichment devices. Because sexual and aggressive behavioral problems in men have been treated with the antiandrogen, cyproterone acetate (CA), the efficacy of CA was tested on reducing self-aggression in eight singly-housed adult male rhesus macaques. Baseline behavior was recorded for 14 weeks, followed by treatment with 50 mg CA/wk for 8 weeks, then 100 mg CA/wk for 4 weeks, and an additional 4 weeks of observation after treatment cessation. A repeated measure of variance analysis (P = 0.5) was used to analyze results. The main findings during CA treatment were (1) the occurrence frequency of self-biting and some other abnormal behaviors was significantly reduced, but not eliminated; (2) blood levels of testosterone were significantly reduced; (3) but the frequency of masturbation and sperm counts did not drop. It was concluded that CA is a partially effective long-term treatment for adult male rhesus macaques with behavioral problems that include self-destructive actions. The findings suggest that self-directed aggressive behavior is modulated by testosterone and/or other factors.