MALE RHESUS SELF AGGRESSION ANTI ANDROGEN CYPROTERONE ACETATE IMPROVE WELL BEING

自咬在雄性非人灵长类动物中是一个严重的问题 那不能是集体住房。在以下方面取得了有限的成功 通过减少独居雄性恒河猴的自咬行为 用浓缩设备改善环境。因为性爱 男性的攻击性行为问题已经得到了治疗 抗雄激素，环丙孕酮(CA)，检测CA的疗效 8只独居成年雄性恒河猴减少自我攻击性的研究 猕猴。记录了14周的基线行为，然后是 先用50 mg CA/wk治疗8周，再用100 mg CA/wk治疗4周。 停药后再观察4周。一个 采用重复测量方差分析(P=0.5)进行统计学分析 结果。CA治疗过程中的主要发现是：(1) 自咬等异常行为的发生频率 显著减少，但并未消除；(2)血液中 睾丸素显著降低；(3)但 手淫和精子数量没有下降。由此得出结论：CA 是一种部分有效的长期治疗成年雄性恒河猴 有行为问题的猕猴，包括自毁 行为。研究结果表明，自我导向的攻击性行为 受睾丸激素和/或其他因素的调节。

Self-biting presents a serious problem in male nonhuman primates that cannot be group-housed. Limited success has been experienced in reducing self-biting in singly-housed male rhesus macaques by enhancing their environment with enrichment devices. Because sexual and aggressive behavioral problems in men have been treated with the antiandrogen, cyproterone acetate (CA), the efficacy of CA was tested on reducing self-aggression in eight singly-housed adult male rhesus macaques. Baseline behavior was recorded for 14 weeks, followed by treatment with 50 mg CA/wk for 8 weeks, then 100 mg CA/wk for 4 weeks, and an additional 4 weeks of observation after treatment cessation. A repeated measure of variance analysis (P = 0.5) was used to analyze results. The main findings during CA treatment were (1) the occurrence frequency of self-biting and some other abnormal behaviors was significantly reduced, but not eliminated; (2) blood levels of testosterone were significantly reduced; (3) but the frequency of masturbation and sperm counts did not drop. It was concluded that CA is a partially effective long-term treatment for adult male rhesus macaques with behavioral problems that include self-destructive actions. The findings suggest that self-directed aggressive behavior is modulated by testosterone and/or other factors.