SELF AGGRESSION IN MALE RHESUS: ANTIANDROGEN, CYPROTERONE ACETATE FOR WELL BEING

雄性恒河猴的自我攻击：抗雄激素、醋酸环丙孕酮促进健康

• 批准号: 6277320
• 负责人: G G EATON
• 金额: $ 7.42万
• 依托单位: OREGON REGIONAL PRIMATE RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277320
• 关键词: Mammalia; Primates; biological products; drug /agent; endocrine gland /system; psychology; reproductive system

Self-injurious behavior (SIB) presents a serious problem in laboratory macaques that cannot be socially housed for scientific reasons. It is also a serious problem among significant numbers of institutionalized children and adults where it is often associated with different forms of brain dysfunction. In macaques, SIB is associated with conditions of social deprivation during early development. We have experienced limited success in reducing SIB in macaques by enhancing their environment with enrichment devices. Psychotropic drugs also help, but problems are associated with their use. Because sexual and aggressive behavioral problems in men have been treated with drugs containing progestin and androgenic profiles, we tested the efficacy of cyproterone acetate (CA) on reducing SIB in eight singly-housed, adult male rhesus macaques. The main findings were 1) the frequency of occurrence of SIB, and some other atypical behaviors, was significantly reduced after several weeks of CA treatment; 2) blood levels of testosterone were also significantly reduced, but 3) frequency of masturbation and sperm counts did not drop with the treatment (5-10 mg/kg/wk CA). We concluded that CA is a partially effective, long-term treatment (3 months) for adult male macaques whose behavior problems include SIB. However, in addition to CA, other interventions are needed to eliminate SIB. The findings suggest that SIB is modulated by progestins or androgens. The ability of CA to reduce SIB, but not the frequency of masturbation or sperm counts, has led to the hypothesis that its androgen-like action is sufficient to maintain sexual behavior, but its progestin-like action may decrease aggressive behavior. This may also indicate a separation of the neurophysiological mechanisms that control sexual and aggressive behavior. We conclude that CA would be useful in treatment of SIB, especially when it is desired to maintain reproductive capabilities in the subjects.

自我伤害行为（SIB）是一个严重的问题， 实验室猕猴，不能被社会圈养， 原因 这也是一个严重的问题， 被收容的儿童和成人经常与之相关 患有不同形式的脑功能障碍 在猕猴中，SIB 与早期社会剥夺状况有关的 发展 我们在减少SIB方面取得了有限的成功， 通过富集装置改善猕猴的环境。 精神药物也有帮助，但问题与他们的治疗有关。 使用. 因为男性的性和攻击性行为问题 接受过含有睾丸素和雄激素的药物治疗， 我们测试了醋酸环丙孕酮（CA）在降低 八只单独圈养的成年雄性恒河猴 的主要结论 1）SIB的发生频率，以及其他一些非典型的 行为，在CA几周后显著减少 治疗; 2）血液睾酮水平也显着 减少，但3）手淫频率和精子计数没有 随着治疗（5-10 mg/kg/wk CA）而下降。 我们得出结论，CA是一个 成年男性部分有效的长期治疗（3个月） 行为问题包括SIB的猕猴。 不过除了 CA，需要其他干预措施来消除SIB。 这些发现 提示SIB受孕激素或雄激素调节。 的能力 CA减少SIB，但不是手淫或精子的频率 计数，导致了一种假设，即它的雄激素样作用是 足以维持性行为，但其类似孕激素的作用 可以减少攻击性行为。 这也可能表明分居 控制性行为的神经生理机制， 攻击性行为 我们得出结论，CA将是有用的治疗 特别是当需要维持生殖能力时， 科目中的能力。