SELF AGGRESSION IN MALE RHESUS: ANTIANDROGEN, CYPROTERONE ACETATE FOR WELL BEING

自我伤害行为(SIB)是一个严重的问题 实验室猕猴不能作为科学研究的社会住所 理由。它也是一个严重的问题在相当数量的 经常与之联系在一起的机构儿童和成人 有不同形式的大脑功能障碍。在猕猴中，SIB是 与早期的社会剥夺状况有关 发展。我们在减少SIB方面取得的成功有限 通过使用富集器改善猕猴的环境。 精神药物也有帮助，但问题与他们的 使用。因为男性的性行为和攻击性行为问题 接受过含有孕激素和雄激素特征的药物治疗， 本实验观察了醋酸环丙孕酮(CA)对小鼠SIB的影响。 八只独居成年雄性恒河猴。主要发现 1)SIB的发生频率，以及其他一些不典型的 行为，在CA治疗几周后显著减少 治疗；2)血液中的睾酮水平也显著 减少，但手淫频率和精子数量并没有 随着治疗(5-10 mg/kg/wk CA)而下降。我们得出结论，CA是一个 成年男性部分有效的长期治疗(3个月) 行为问题包括SIB的猕猴。然而，除了 CA，还需要其他干预措施来消除SIB。调查结果 提示SIB受孕激素或雄激素的调节。一种能力 CA可以减少SIB，但不能减少手淫或精子的频率 的作用，导致假设其雄激素样作用是 足以维持性行为，但它的孕激素样作用 可能会减少攻击性行为。这也可能意味着分离。 控制性行为和性行为的神经生理机制 攻击性行为。我们得出结论，CA在治疗中将是有用的 特别是在希望保持生殖能力的情况下 受试者的能力。

Self-injurious behavior (SIB) presents a serious problem in laboratory macaques that cannot be socially housed for scientific reasons. It is also a serious problem among significant numbers of institutionalized children and adults where it is often associated with different forms of brain dysfunction. In macaques, SIB is associated with conditions of social deprivation during early development. We have experienced limited success in reducing SIB in macaques by enhancing their environment with enrichment devices. Psychotropic drugs also help, but problems are associated with their use. Because sexual and aggressive behavioral problems in men have been treated with drugs containing progestin and androgenic profiles, we tested the efficacy of cyproterone acetate (CA) on reducing SIB in eight singly-housed, adult male rhesus macaques. The main findings were 1) the frequency of occurrence of SIB, and some other atypical behaviors, was significantly reduced after several weeks of CA treatment; 2) blood levels of testosterone were also significantly reduced, but 3) frequency of masturbation and sperm counts did not drop with the treatment (5-10 mg/kg/wk CA). We concluded that CA is a partially effective, long-term treatment (3 months) for adult male macaques whose behavior problems include SIB. However, in addition to CA, other interventions are needed to eliminate SIB. The findings suggest that SIB is modulated by progestins or androgens. The ability of CA to reduce SIB, but not the frequency of masturbation or sperm counts, has led to the hypothesis that its androgen-like action is sufficient to maintain sexual behavior, but its progestin-like action may decrease aggressive behavior. This may also indicate a separation of the neurophysiological mechanisms that control sexual and aggressive behavior. We conclude that CA would be useful in treatment of SIB, especially when it is desired to maintain reproductive capabilities in the subjects.