SINGLE SHOT DIFFUSION MEASUREMENT

单次扩散测量

• 批准号: 6118711
• 负责人: SHARON PELED
• 金额: $ 0.11万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-15 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118711
• 关键词: bioengineering /biomedical engineering; biological products; biomedical resource; nucleic acids; proteins

We have introduced a single-shot pulsed gradient stimulated echo sequence to address the challenges of diffusion measurements of laser polarized 3 He and 129xe gas. Laser polarization enhances the NMR sensitivity of these noble gases by >10', but creates an unstable, non-thermal polarization that is not readily renewable. We have devised a new method that permits parallel acquisition of the several measurements required to determine a diffusive attenuation curve. In principle, the complete NMR characterization of a sample's diffusion behavior may be accomplished in a single measurement, using only a single polarization step. As a demonstration, we have measured the diffusion coefficient of a sample of laser polarized 129xe gas via this method.

我们引入了一个单发脉冲梯度刺激的回波 序列解决激光扩散测量的挑战 偏光3 HE和129XE气体。 激光极化增强了NMR 这些贵重气的敏感性> 10'，但会产生不稳定的， 不容易续签的非热极化。 我们有 设计了一种新方法，允许并行获取几种 确定扩散衰减曲线所需的测量。 在 原理，样品扩散的完整NMR表征 行为可以在单个测量中完成，仅使用 单极化步骤。 作为演示，我们已经测量了 激光偏振129x气体样品的扩散系数通过 此方法。