WATER DIFFUSION, T2, & COMPARTMENTATION IN FROG SCIATIC NERVE

水扩散，T2，

• 批准号: 6118674
• 负责人: SHARON PELED
• 金额: $ 0.11万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-15 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118674
• 关键词: biological products; biomedical equipment development; biomedical resource; proteins; technology /technique

A- potential relationship between structural compartments in neural tissue and NMR parameters may increase the specificity of MRI in diagnosing diseases. Nevertheless, our understanding of MR of nerves and white matter is limited, particularly the influence of various water compartments on the MR signal is not known. In this study, components of the 'H transverse relaxation decay curve in frog peripheral nerve were correlated with the diffusion characteristics of the water in the nerve. Three T2'Swere identified with nerve. Water mobility was found to be unrestricted on the timescale of 100 ms in the component of the signal with the intermediate T2 time, suggesting some contribution from the interstitial space to this T, component. Restricted diffusion was observed in the component with the longest T2 time, supporting the assignment of at least part of the spins contributing to this component to an intracellular compartment. The observed nonexponential behavior of the diffusion attenuation curves was investigated and shown to be potentially caused by the wide range of axon sizes in the nerve.

A-结构隔室之间的潜在关系 神经组织和NMR参数可能会提高MRI的特异性 在诊断疾病中。 然而，我们对MR的理解 神经和白质是有限的，尤其是 MR信号上的各种水室尚不清楚。 在这个 研究，青蛙中'H横向松弛衰减曲线的成分 周围神经与 神经中的水。 三个T2'Swere神经识别。 水 发现移动性在100毫秒的时间表上不受限制地限制 信号与中间T2时间的组成部分，表明 从间隙空间到该T组件的一些贡献。 在最长T2的组件中观察到限制扩散 时间，支持至少一部分旋转的分配 为此组件造成细胞内室。 这 观察到扩散衰减曲线的非义务行为 被调查并证明是由于广泛范围引起的 神经中的轴突尺寸。