MAGNETIC FIELD ORIENTED CRYSTALLIZATION OF CUTPP

CUTPP 的磁场定向结晶

• 批准号: 6118855
• 负责人: WITOLD K SUBCZYNSKI
• 金额: $ 0.92万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118855
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical resource; lipids

During slow evaporation of chloroform from a saturated CuTPP solution, placed in magnetic field, CuTPP crystals are formed on the capillary walls with planes of CuTPP molecules oriented parallel to the magnetic field. Without the magnetic field, crystals are oriented randomly. The degree of crystal orientation depends on the strength of the magnetic field reaching a maximum value at about 1000G. Magnetic alignment arises from the anisotophy of the paramagnetic susceptibility tensor delta. We were trying to employ this effect to orient lipid bilayer membranes, bicells containing a mixture of DMPC/DHPC = 3 and CuTPP. We used other planar copper and iron complexes. We hoped that we can orient membranes at X-band (3000G) similarily as others at NMR magnetic fields.

从饱和CuTPP缓慢蒸发氯仿的过程中 溶液，置于磁场中，CuTPP晶体在 具有平行取向的CuTPP分子平面的毛细管壁 磁场。没有磁场，晶体就会定向 随机的。晶体取向的程度取决于强度 在约1000G处达到最大值的磁场。 磁排列是由顺磁的各向异性引起的。 磁化率张量增量。我们试图利用这种效应来 定向类脂双层膜，双细胞含有 DMPC/DHPC=3和CuTPP。我们用的是其他的平面铜和铁 复合体。我们希望我们能在X波段(3000G)定向薄膜 与在核磁共振磁场中的其他物质相似。