SELF ASSOCIATION OF COPPER(II) TETRAPHENYLPORPHINE IN LIPID BILAYERMEMBRANES
SELF ASSOCIATION OF COPPER(II) TETRAPHENYLPORPHINE IN LIPID BILAYERMEMBRANES
批准号:
6307900
负责人:
WITOLD K SUBCZYNSKI
金额:
$1.13万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-03-01 至 2001-02-28
中文摘要
已发现四苯基卟吩铜 (II) (CuTPP)
有利地分配为二肉豆蔻酰磷脂酰胆碱 (DMPC)
囊泡。 定向 DMPC 膜的 EPR 谱
计算机模拟表明 CuTPP 是优先取向的
分子平面垂直于双层表面
低(小于或等于 1/100)CuTPP/DMPC 摩尔比。 然而,
对于高(约 1/25)CuTPP/DMPC 摩尔比,平面
分子变得平行于膜表面。 测量值
CuTPP 与硬脂酸的硝基氧部分之间的碰撞率
使用酸自旋标记位于膜的不同深度
饱和恢复 EPR 光谱得出的结论是
CuTPP取向的变化是自缔合的结果
(结晶)CuTPP 分子靠近脂质双层中心。
自缔合过程取决于 CuTPP/DMPC 摩尔
比例和样品制备后的时间。
英文摘要
Copper (II) tetraphenylporphine (CuTPP) has been found to
partition favorably into dimyristoylphosphatidylcholine (DMPC)
vesicles. EPR spectra of oriented DMPC membranes together with
computer simulations show that the CuTPP is preferentially oriented
with the plane of the molecule perpendicular to the bilayer surface at
low (less than or equal to 1/100) CuTPP/DMPC molar ratio. However,
for a high (ca. 1/25) CuTPP/DMPC molar ratio, the plane of the
molecule becomes parallel to the membrane surface. Measurements of
the collision rate between CuTPP and the nitroxide moiety of stearic
acid spin labels located at different depths in the membrane using
saturation recovery EPR spectroscopy led to the conclusion that the
change of the CuTPP orientation is the result of self-association
(crystallization) of CuTPP molecules near the lipid bilayer center.
The self-association process depends both on the CuTPP/DMPC molar
ratio and the time after sample preparation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Is Cholesterol Crystalline Domain a Barrier to Oxygen Transport in the Eye Lens?
-
批准号:7558402
-
项目类别:
-
资助金额:$3.9万
-
财政年份:2009
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Is Cholesterol Crystalline Domain a Barrier to Oxygen Transport in the Eye Lens?
-
批准号:8011951
-
项目类别:
-
资助金额:$3.22万
-
财政年份:2009
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Is Cholesterol Crystalline Domain a Barrier to Oxygen Transport in the Eye Lens?
-
批准号:7763233
-
项目类别:
-
资助金额:$3.25万
-
财政年份:2009
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Cholesterol Crystalline Domain Function in Eye Lens: EPR Spin-Labeling Studies
-
批准号:8585066
-
项目类别:
-
资助金额:$32.18万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Lipid Rafts in Eye Lens: Discrimination by Pulse EPR
-
批准号:7171797
-
项目类别:
-
资助金额:$29.51万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Cholesterol Crystalline Domain Function in Eye Lens: EPR Spin-Labeling Studies
-
批准号:7994801
-
项目类别:
-
资助金额:$32.83万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Cholesterol Crystalline Domain Function in Eye Lens: EPR Spin-Labeling Studies
-
批准号:8374124
-
项目类别:
-
资助金额:$31.19万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Lipid Rafts in Eye Lens: Discrimination by Pulse EPR
-
批准号:6987802
-
项目类别:
-
资助金额:$29.78万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Cholesterol Crystalline Domain Function in Eye Lens: EPR Spin-Labeling Studies
-
批准号:7780890
-
项目类别:
-
资助金额:$33.36万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Liquid Rafts in Eye Lens: Discrimination by Pulse EPR
-
批准号:6869824
-
项目类别:
-
资助金额:$31.89万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Lipid Domains in Lens Membranes of a Single Eye: EPR Spin-Labeling Studies
-
批准号:9070731
-
项目类别:
-
资助金额:$34.63万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Lipid Rafts in Eye Lens: Discrimination by Pulse EPR
-
批准号:7539888
-
项目类别:
-
资助金额:$29.29万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Lipid Rafts in Eye Lens: Discrimination by Pulse EPR
-
批准号:7344667
-
项目类别:
-
资助金额:$28.82万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
Cholesterol Crystalline Domain Function in Eye Lens: EPR Spin-Labeling Studies
-
批准号:8197371
-
项目类别:
-
资助金额:$32.83万
-
财政年份:2004
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
EFFECTS OF CAROTENOIDS ON PHYSICAL PROPERTIES OF LIPID BILAYER MEMBRANES
-
批准号:6307901
-
项目类别:
-
资助金额:$1.13万
-
财政年份:2000
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
SPIN LABEL EFFECTS OF MEMBRANE SPANNING PEPTIDE L24 & LA12 ON POPC MEMBRANES
-
批准号:6307898
-
项目类别:
-
资助金额:$1.13万
-
财政年份:2000
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
LIQUID CRYSTALLINE LIPID BILAYER MEMBRANES
-
批准号:6307899
-
项目类别:
-
资助金额:$1.13万
-
财政年份:2000
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
SELF ASSOCIATION OF COPPER(II) TETRAPHENYLPORPHINE IN LIPID BILAYER MEMBRANES
-
批准号:6118853
-
项目类别:
-
资助金额:$0.27万
-
财政年份:1999
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
ESR STUDY OF EFFECTS OF MEMBRANE SPANNING PEPTIDE L24 & LA12 ON POPC MEMBRANES
-
批准号:6118854
-
项目类别:
-
资助金额:$0.27万
-
财政年份:1999
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
MAGNETIC FIELD ORIENTED CRYSTALLIZATION OF CUTPP
-
批准号:6118855
-
项目类别:
-
资助金额:$0.92万
-
财政年份:1999
-
负责人:WITOLD K SUBCZYNSKI
-
依托单位:
海外基金