CO-CONNECT: COVID - Curated and Open aNalysis aNd rEsearCh plaTform

CO-CONNECT是一个合作项目，它有四个合作伙伴：杰斐逊（邓迪），谢赫（爱丁堡），霍普金斯（PHE）和昆兰（诺丁汉）。当前的COVID-19大流行已造成数十万人死亡，严重影响了世界各地的卫生系统，并破坏了经济。目前，有有限的证据表明，从COVID-19中康复并有抗体的人可以免受第二次感染，如果是这样，可以持续多久。了解谁具有免疫力对于保护脆弱个体、安全地缩减基于人群的干预措施和管理疾病传播至关重要。这些数据可以帮助我们回答这些关键问题，这些数据是由英国各地的一系列研究小组和临床初级和二级护理机构收集的。由于这是一种新疾病，抗体数据采集的标准还处于起步阶段，因此需要回答关键问题的一些细节还没有被系统地采集。数据的碎片化格局意味着，公共卫生组织和研究人员很难迅速找到和获取他们所需的高质量数据。我们将：-标准化整个英国的抗体数据收集-配置一个基础设施，使来自多个来源的数据集能够进行可信、快速、去识别、安全的分析-回答有关COVID-19免疫力及其对患者结果的影响的关键问题。

CO-CONNECT is a collaborative project and it has four CO-PIs: Jefferson (Dundee), Sheikh (Edinburgh), Hopkins (PHE) and Quinlan (Nottingham).The current COVID-19 pandemic has caused hundreds of thousands of deaths, severely strained health systems and damaged economies across the world. At this time there is limited evidence that people who have recovered from COVID-19 and have antibodies are protected from a second infection and if so, how long that lasts. Understanding who is immune is vital to protect vulnerable individuals, to safely scale back population-based interventions and for managing disease transmission. The data which can help us to answer these key questions have been collected across the UK by a range of research groups and within clinical primary and secondary care settings. As this is a new disease, the standards for antibody data capture are in their infancy so some of the details need to answer the key questions are not being captured systematically. The fragmented landscape of data means that it can be challenging for public health groups and researchers to find and access the high-quality data they need at pace. We will: - Standardise antibody data collection across the UK - Configure an infrastructure which enables trustworthy, fast, de-identified, secure analysis of data sets from across multiple sources - Answer key questions about immunity to COVID-19 and the implications for patient outcomes.