Development of novel anti-cancer and immunosuppressive drugs derived from pineapple stems

开发源自菠萝茎的新型抗癌和免疫抑制药物

• 批准号: nhmrc : 389849
• 负责人: Dr Christian Engwerda
• 金额: $ 31.31万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-novel-anti-pineapple-stems/94391
• 关键词: Development; novel; anti; cancer; immunosuppressive

We have discovered two molecules from pineapple stems that show anti-tumour activity in laboratory studies. One molecule, called ananain, blocks a cancer causing protein called Ras, which is defective in approximately 30% of all cancers. The other molecule, called canizain, stimulates the bodies own immune system to target and kill cancer cells. The proposed research seeks to provide proof of concept of the use of ananain and canizain as drug development targets. Once this early proof of principle phase has been completed, we believe that ananain and canizain would be extremely attractive targets for further investment by a major pharmaceutical company.

我们在实验室研究中发现了菠萝茎中的两种分子具有抗肿瘤活性。一种名为 ananain 的分子可以阻断一种名为 Ras 的致癌蛋白，这种蛋白在大约 30% 的癌症中存在缺陷。另一种分子称为canizain，可刺激人体自身的免疫系统瞄准并杀死癌细胞。拟议的研究旨在提供使用 ananain 和 canizain 作为药物开发目标的概念证明。一旦这一早期原理验证阶段完成，我们相信 ananain 和 canizain 将成为大型制药公司进一步投资的极具吸引力的目标。