Tissue specific antigen presenting cell functions during infection.

感染期间组织特异性抗原呈递细胞的功能。

• 批准号: nhmrc : 613649
• 负责人: Dr Christian Engwerda
• 金额: $ 37.03万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tissue-specific-antigen-functions-infection/76484
• 关键词: Tissue; specific; antigen; presenting; cell

T cell activation is often inefficient following infection or vaccination, resulting in poor control of pathogens. In this grant, we propose to investigate the cellular basis for sub-optimal CD4+ T cell activation following infection. Specifically, we will study the roles of antigen presenting cells in CD4+ T cell activation in an experimental model of visceral leishmaniasis caused by the human protozoan parasite Leishmania donovani.

在感染或接种疫苗后，T细胞的激活往往效率低下，导致对病原体的控制不力。在这项资助中，我们建议调查感染后次优CD4+T细胞激活的细胞学基础。具体地说，我们将在由人类原虫寄生虫杜氏利什曼原虫引起的内脏利什曼病实验模型中，研究抗原提呈细胞在CD4+T细胞激活中的作用。