Discovering novel immune targets for treating infectious diseases

发现治疗传染病的新免疫靶点

• 批准号: nhmrc : GNT1154265
• 负责人: Dr Christian Engwerda
• 金额: $ 71.73万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovering-novel-immune-infectious-diseases/1349128
• 关键词: Discovering; novel; immune; targets; treating

The early establishment of immunoregulatory networks following infection may act to suppress subsequent immune responses to new infections. Therefore, we need to better understand how immune responses develop and are regulated during infectious diseases. In particular, we need to establish whether regulatory mechanisms can be manipulated to improve anti-parasitic immunity without exacerbating disease. This knowledge is vital if important human parasitic diseases are to be eliminated.

感染后早期建立的免疫调节网络可能会抑制随后对新感染的免疫反应。因此，我们需要更好地了解传染病期间免疫反应如何发展和调节。特别是，我们需要确定是否可以操纵调节机制来提高抗寄生虫免疫力而不加剧疾病。如果要消除重要的人类寄生虫病，这些知识至关重要。