The COVID-19 Clinical Neuroscience Study (COVID-CNS)

COVID-19 临床神经科学研究 (COVID-CNS)

• 批准号: MR/V03605X/1
• 负责人: Benedict Michael
• 金额: $ 298.37万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV03605X%2F1
• 关键词: COVID; 19; Clinical; Neuroscience; Study

COVID-19 patients frequently suffer brain problems during the infection and can be left with symptoms of brain injury. Similar problems have been seen in previous pandemics, including Spanish influenza over 100 years ago, but how and why this occurs is poorly understood.We have already been notified of 800 UK patients with these complications due to COVID-19. We have a unique opportunity to understand how these problems occur and develop strategies to prevent and treat them. The questions we will ask include in whom does COVID-19 cause injury? Does it do this by invading the brain? Or by triggering excessive immune responses or interfering with the blood supply to nervous tissue?We will answer these questions through in depth clinical, laboratory, and imaging studies of these 800 patients in comparison to 500 control patients (hospitalised during the pandemic with COVID-19 [400] or without COVID-19 [100]).Without this understanding, we cannot determine whether anti-viral medication, or treatments that modulate the immune system or that improve blood supply will help, and if so in which patients.We will apply this understanding through our World Health Organisation-commissioned Task Force (co-Chair Michael) to develop clinical care guidelines, identify patients for targeted clinical trials, and ultimately improve patient outcomes.We will consent all participants to the NIHR BioResource, establishing COVID-CNS as a trial ready cohort and ensuring data and sample access for other researchers.N.B. COVID-CNS is jointly led by co-PIs Benedict Michael and Gerome Breen

新冠肺炎患者在感染期间经常出现脑部问题，并可留下脑损伤症状。类似的问题在以前的大流行中也出现过，包括100多年前的西班牙流感，但人们对这种情况是如何发生的以及为什么会发生还不太清楚。我们已经接到了800名英国患者因新冠肺炎而出现这些并发症的通知。我们有一个独特的机会来了解这些问题是如何发生的，并制定预防和治疗它们的战略。我们要问的问题包括新冠肺炎会对谁造成伤害？它是通过侵入大脑来做到这一点的吗？或者通过触发过度的免疫反应或干扰神经组织的血液供应？我们将通过深入的临床、实验室和成像研究来回答这些问题，并将这800名患者与500名对照组患者(在疫情期间使用新冠肺炎或不使用新冠肺炎[100]住院)进行比较。如果不了解这些，我们就无法确定抗病毒药物或调节免疫系统或改善血液供应的治疗是否会有帮助，如果是的话，我们将通过世界卫生组织委托的特别工作组(联席主席迈克尔)应用这种了解来制定临床护理指南，确定患者进行有针对性的临床试验。并最终改善患者的预后。我们将同意所有参与者加入NIHR生物资源，将COVID-CNS建立为试验准备队列，并确保其他研究人员可以访问数据和样本。

项目成果

Neuroimmune disorders in COVID-19.

• DOI: 10.1007/s00415-022-11050-w
• 发表时间: 2022-06
• 期刊: Journal of neurology
• 影响因子: 6
• 作者: Ariño H;Heartshorne R;Michael BD;Nicholson TR;Vincent A;Pollak TA;Vogrig A
• 通讯作者: Vogrig A

Additional file 1 of Increased volume of cerebral oedema is associated with risk of acute seizure activity and adverse neurological outcomes in encephalitis - regional and volumetric analysis in a multi-centre cohort

脑水肿体积增加与脑炎急性癫痫发作和不良神经系统结局的风险相关的附加文件 1 - 多中心队列的区域和体积分析

• DOI: 10.6084/m9.figshare.21520209
• 发表时间: 2022
• 作者: Alam A

Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality.

• DOI: 10.1371/journal.pntd.0010952
• 发表时间: 2022-11
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8

Mental health outcomes of encephalitis: an international web-based study

脑炎的心理健康结果：一项国际网络研究

• DOI: 10.1101/2023.02.03.23285344
• 发表时间: 2023
• 作者: Abdat Y

Increased volume of cerebral oedema is associated with risk of acute seizure activity and adverse neurological outcomes in encephalitis - regional and volumetric analysis in a multi-centre cohort.

• DOI: 10.1186/s12883-022-02926-5
• 发表时间: 2022-11-07
• 期刊: BMC NEUROLOGY
• 影响因子: 2.6
• 作者: Alam, A. M.;Chen, J. P. K.;Wood, G. K.;Facer, B.;Bhojak, M.;Das, K.;Defres, S.;Marson, A.;Granerod, J.;Brown, D.;Thomas, R. H.;Keller, S. S.;Solomon, T.;Michael, B. D.
• 通讯作者: Michael, B. D.