NEUROBEHAVIORAL EFFECTS OF PARTIAL SLEEP DEPRIVATION

部分睡眠剥夺对神经行为的影响

• 批准号: 6113260
• 负责人: DAVID F DINGES
• 金额: $ 2.51万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113260
• 关键词: behavioral /social science research tag; clinical research; cognition; human subject; mood disorders; neuropsychological tests; performance; psychobiology; sleep deprivation; wakefulness

This project seeks to determine how waking neurobehavioral functions (sleep propensity, cognitive performance, sleepiness, and mood) are affected by partial sleep deprivation (PSD). PSD has been identified as a serious public health problem being experienced daily by millions of people as a result of medical, psychiatric, and sleep disorders, as well as social demands (work, family, travel). Although highly prevalent, little scientific work has been done on the nightly duration of sleep and number of days of PSD that will lead to daytime sleepiness, involuntary sleep episodes, performance failures-- information that is essential to determining the level of PSD that could result n accidents (e.g., motor vehicle). In a preliminary study, we developed a protocol for studying PSD and demonstrated the sensitivity of a set of neurobehavioral measures to sleep restriction over 1 week. Utilizing this approach, a randomized control trial using independent groups was initiated to test the effecs on waking function of the types of sleep restriction most commonly experienced by people. The purpose of this study is to determine the nature of the cumulative waking changes in neurobehavioral functions engendered by restricting nocturnal sleep to 4.0 hrs, 6.0 hrs, and 8.0 hrs (control) per night for 14 consecutive nights, when the sleep is placed at different circadian phases. Following a 7-14 day period at home, during which time the subjects are monitored to ensure they have a stable sleep/wake cycle, subjects will live in the Inpatient Study Unit of the CRC for 20 consecutive days, during which time their sleep and waking neurobehavioral functions are monitored. Following 3 baseline days of 8-10 hr sleep/night, subjects will be randomly assigned to one of the three sleep restriction conditions (4,6,8 hr/night) for the next 14 days, followed by 3 days of recovery sleep (8 hr/night). Changes in sleep polysomnograpy and waking neurobehavioral functions at different circadian phases across the 2-week period of sleep restriction are compared among the three groups.

这个项目试图确定部分睡眠剥夺(PSD)是如何影响清醒的神经行为功能(睡眠倾向、认知表现、困倦和情绪)的。由于医疗、精神和睡眠障碍以及社会需求(工作、家庭、旅行)，PSD已被确定为数百万人每天经历的严重公共卫生问题。尽管很普遍，但很少有关于夜间睡眠持续时间和导致白天嗜睡、非自愿睡眠发作、表现不佳的PSD天数的科学工作--这些信息对于确定可能导致事故的PSD水平至关重要(例如，机动车辆)。在一项初步研究中，我们制定了一项研究PSD的方案，并展示了一系列神经行为指标对一周以上睡眠限制的敏感性。利用这一方法，启动了一项使用独立小组的随机对照试验，以测试人们最常经历的睡眠限制类型对唤醒功能的影响。这项研究的目的是确定连续14个晚上将夜间睡眠限制在每晚4.0小时、6.0小时和8.0小时(对照组)时，当睡眠处于不同的昼夜节律时，神经行为功能的累积觉醒变化的性质。在家中7-14天的时间内，受试者将接受监测，以确保他们有一个稳定的睡眠/清醒周期，受试者将在儿童权利中心的住院研究单元连续居住20天，在此期间，他们的睡眠和清醒的神经行为功能得到监测。在每晚8-10小时的3天基线睡眠后，受试者将被随机分配到三种睡眠限制条件之一(4，6，8小时/晚)，然后是3天的恢复睡眠(8小时/晚)。比较三组在两周睡眠限制期间不同昼夜节律阶段的睡眠多眠和清醒神经行为功能的变化。