ANTIPLATELET EFFECT AND PHARMACOKINETIC COMPARISON OF ORAL VS RECTAL ASPIRIN

尽管没有数据表明阿司匹林作为一种抗血小板药物的有效性，但直肠阿司匹林目前正用于住院的急性心肌缺血综合征患者，这些患者由于呕吐或胃肠道病理状况而昏迷或无法耐受口服药物。这项随机、双盲、安慰剂对照、完全交叉的研究旨在比较口服阿司匹林和直肠阿司匹林(325 mg片剂和300 mg栓剂)对健康中年志愿者体外血小板聚集和抑制血栓素B2产生的作用的开始和程度。

Despite an absence of data demonstrating efficacy as an antiplatelet agent, rectal aspirin is currently being administered to hospitalized patients with acute myocardial ischemic syndromes who are unconscious or who cannot tolerate oral medications due to emesis or pathological conditions of the gastrointestinal tract. This randomized, double-blinded, placebo-controlled, complete crossover study, is designed to compare the onset and magnitude of effects of ex-vivo platelet aggregation and supression of thromboxane B2 production, between oral and rectal aspirin (325 mg tablet vs 300 suppository) in healthy middle-aged volunteers.