ANTIPLATELET EFFECT AND PHARMACOKINETIC COMPARISON OF ORAL VS RECTAL ASPIRIN
口服与直肠阿司匹林的抗血小板作用和药代动力学比较
基本信息
- 批准号:6274534
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-04-15 至 1998-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It is believed that platelet aggregation is, in part, responsible for
the development of cardiovascular diseases such as unstable angina and
acute myocardial infarction. Aspirin attenuates platelet aggregation,
presumably by irreversibly inhibiting cyclooxygenase, an enzyme
responsible for the formation of thromboxane A(2), a potent stimulator
of platelet aggregation. Aspirin has been shown to significantly reduce
the incidence of vascular events and is widely recommended for may
cardiovascular diseases. Numerous studies have documented the
pharmacokinetics and antiplatelet activity of immediate-release oral
aspirin. However, there have been no published studies of aspirin
pharmacokinetics or pharmacodynamics following rectal administration
although information on salicylate concentrations following rectal
administration does exist.
This will be a single-blind, crossover pilot study of the antiplatelet
effects and pharmacokinetics of aspirin administered as a single 300 mg
rectal suppository and, separately, a 325 mg immediate-release tablet
in 4 healthy, middle-aged adults.
This project will accomplish the following objectives:
a. Compare the onset and magnitude of effects following a single
immediate-release oral and rectal dose of aspirin on ex vivo platelet
aggregation and suppression of thromboxane B(2) (TXB(2)) synthesis
b. Compare the volumes of distribution, absorption rate constants,
elimination rate constants, total body clearances, lag times to
measurable aspirin concentrations and relative bioavailabilities of
orally- and rectally-administered aspirin.
据信,血小板聚集在一定程度上导致了
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SARAH A SPINLER其他文献
SARAH A SPINLER的其他文献
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{{ truncateString('SARAH A SPINLER', 18)}}的其他基金
ASA EFFECTS ON ANTIHYPERTENSIVE EFFICACIES OF ENALAPRIL AND LOSARTAN
ASA 对依那普利和氯沙坦抗高血压疗效的影响
- 批准号:
6113275 - 财政年份:1998
- 资助金额:
$ 2.5万 - 项目类别:
ASA EFFECTS ON ANTIHYPERTENSIVE EFFICACIES OF ENALAPRIL AND LOSARTAN
ASA 对依那普利和氯沙坦抗高血压疗效的影响
- 批准号:
6274509 - 财政年份:1998
- 资助金额:
$ 2.5万 - 项目类别:
EFFECT OF ASCORBIC ACID & ALPHA TOCOPHEROL IN HYPERLIPIDEMIA
抗坏血酸的作用
- 批准号:
6263587 - 财政年份:1998
- 资助金额:
$ 2.5万 - 项目类别:
ANTIPLATELET EFFECT AND PHARMACOKINETIC COMPARISON OF ORAL VS RECTAL ASPIRIN
口服与直肠阿司匹林的抗血小板作用和药代动力学比较
- 批准号:
6113300 - 财政年份:1998
- 资助金额:
$ 2.5万 - 项目类别:
EFFECT OF ASCORBIC ACID AND ALPHA TOCOPHEROL IN HYPERLIPIDEMIA
抗坏血酸和α-生育酚对高脂血症的作用
- 批准号:
6244407 - 财政年份:1997
- 资助金额:
$ 2.5万 - 项目类别:
ANTIPLATELET EFFECTS OF RECTAL VS ORAL ASPIRIN IN HEALTHY MIDDLE AGED VOLUNTEERS
直肠给药与口服阿司匹林对健康中年志愿者的抗血小板作用
- 批准号:
5216081 - 财政年份:
- 资助金额:
$ 2.5万 - 项目类别:
ASA EFFECTS ON ANTIHYPERTENSIVE EFFICACIES OF ENALAPRIL AND LOSARTAN
ASA 对依那普利和氯沙坦抗高血压疗效的影响
- 批准号:
6327869 - 财政年份:
- 资助金额:
$ 2.5万 - 项目类别:
EFFECT OF ASCORBIC ACID & ALPHA TOCOPHEROL IN HYPERLIPIDEMIA
抗坏血酸的作用
- 批准号:
6335111 - 财政年份:
- 资助金额:
$ 2.5万 - 项目类别:
EFFECT OF ASCORBIC ACID & ALPHA TOCOPHEROL IN HYPERLIPIDEMIA
抗坏血酸的作用
- 批准号:
6303291 - 财政年份:
- 资助金额:
$ 2.5万 - 项目类别:
EFFECT OF ASCORBIC ACID AND ALPHA TOCOPHEROL IN HYPERLIPIDEMIA
抗坏血酸和α-生育酚对高脂血症的作用
- 批准号:
5216037 - 财政年份:
- 资助金额:
$ 2.5万 - 项目类别:
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