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INTESTINAL PERMEABILITY OF CYCLOSPORIN A

INTESTINAL PERMEABILITY OF CYCLOSPORIN A
环孢菌素 A 的肠道渗透性
批准号：
6113512
负责人：
GORDON L AMIDON
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113512
关键词：
P glycoprotein clinical research cyclosporines cytochrome P450 gastrointestinal absorption /transport human subject jejunum membrane permeability perfusion

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中文摘要
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英文摘要
The effective intestinal permeability (Peff) of cyclosporin A (CsA) and interindividual variability of CsA Peff will be determined in the upper jejunum of healthy volunteers by using a regional intestinal perfusion technique. The amount of P-glycoprotein and Cytochrome P450 IIIA4 (CYP3A4) in the intestine will be measured to examine the potential contribution of intestinal secretion and metabolism to the Peff of CsA.
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Novel Transport and Activation Strategy to Improve the Bioavailability of Targeted Prodrugs
Novel Transport and Activation Strategy to Improve the Bioavailability of Targeted Prodrugs
INTESTINAL PERMEABILITY OF CYCLOSPORIN A
PELLET GASTRIC EMPTYING TEST (PGET)
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