MEASUREMENTS FOR TUMOR BLOOD FLOW BY PET USING H2O IN LUNG CANCER

使用 H2O 测量肺癌中的肿瘤血流

• 批准号: 6263709
• 负责人: TATSUYA HIGASHI
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263709
• 关键词: blood flow measurement; body water; clinical research; diagnosis quality /standard; human subject; lung neoplasms; neoplasm /cancer diagnosis; positron emission tomography

Much current interest exists in treating cancer with agents that may reduce tumor blood flow through reducing angiogenesis. In addition, tumor blood flow heterogeneity is known to be related to poor treatment response in malignant tumors. Despite the importance of tumor blood flow, there has been little systematic study of the reproducibility of minimally invasive tumor blood flow measurement studies using positron emission tomography (PET) in untreated cancer patients. The purpose of this investigation is to evaluate the precision of repeated measurements of tumor blood flow with (oxygen -15)-water (0-15-water) in untreated human lung cancers.

目前人们对通过减少血管生成来减少肿瘤血流量的药物治疗癌症非常感兴趣。此外，已知肿瘤血流异质性与恶性肿瘤治疗反应差有关。尽管肿瘤血流的重要性，但在未经治疗的癌症患者中使用正电子发射断层扫描（PET）进行微创肿瘤血流测量研究的可重复性方面，还很少有系统的研究。本研究的目的是评估（氧-15）-水（0-15-水）在未经治疗的人肺癌中重复测量肿瘤血流量的精度。