MEASUREMENTS FOR TUMOR BLOOD FLOW BY PET USING H2O IN LUNG CANCER

使用 H2O 测量肺癌中的肿瘤血流

基本信息

  • 批准号:
    6303496
  • 负责人:
  • 金额:
    $ 0.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1999
  • 资助国家:
    美国
  • 起止时间:
    1999-12-01 至 2001-02-28
  • 项目状态:
    已结题

项目摘要

Low tumor blood flow and resultant tumor hypoxia are recognized as important mechanisms of resistance to anticancer treatment such as radiotherapy or chemotherapy. Therefore, drugs that can nearly totally reduce new blood vessel formation and thus limit blood flow are receiving considerable interest of therapeutics. Thus a non-invasive and quantitative method is needed in order to investigate the pretreatment and post-treatment status of tumor blood flow. However, there is no well-established clinical measurement for this purpose. Positron emission tomography (PET) is a noninvasive method to study tissue physiology and metabolism in vivo. The measurement of [oxygen-15]-water (O-15-water) intravenous-injection with PET has shown accuracy in analyzing regional blood flow of brain or myocardium. It has been shown that measurement of O-15-water diffusion with PET in tumors is feasible in a measurement of tumor blood flow. While the O-15-water method has been validated in microsphere studies in animal models, it has not been assessed for precision in human tumor in vivo. Much current interest exists in treating cancer with agents that may reduce tumor blood flow through reducing angiogenesis. In addition, tumor blood flow heterogeneity is known to be related to poor treatment response in malignant tumors. Despite the importance of tumor blood flow, there has been little systematic study of the reproducibility of minimally invasive tumor blood flow measurement studies using positron emission tomography (PET) in untreated cancer patients. The aim of the present study is: To evaluate the reproducibility of quantitative tumor blood flow measurement using O-15 water method in untreated lung cancers and other large tumors.
肿瘤低血流量和由此产生的肿瘤缺氧被认为是对放疗或化疗等抗癌治疗产生耐药性的重要机制。因此,能够几乎完全减少新血管形成从而限制血流量的药物正受到人们极大的关注。因此,需要一种无创、定量的方法来研究肿瘤血流治疗前后的状况。然而,目前尚无完善的临床测量方法。正电子发射断层扫描(PET)是一种研究体内组织生理和代谢的无创方法。PET测量氧-15-水(O-15-water)静脉注射在分析脑或心肌局部血流方面显示出准确性。研究表明,用PET测量o -15水在肿瘤中的扩散在测量肿瘤血流中是可行的。虽然o -15-水方法已在动物模型的微球研究中得到验证,但尚未评估其在人体肿瘤中的精确性。目前人们对通过减少血管生成来减少肿瘤血流量的药物治疗癌症非常感兴趣。此外,已知肿瘤血流异质性与恶性肿瘤治疗反应差有关。尽管肿瘤血流的重要性,但在未经治疗的癌症患者中使用正电子发射断层扫描(PET)进行微创肿瘤血流测量研究的可重复性方面,还很少有系统的研究。本研究的目的是:评价O-15水法在未经治疗的肺癌和其他大肿瘤中定量测量肿瘤血流量的可重复性。

项目成果

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TATSUYA HIGASHI其他文献

TATSUYA HIGASHI的其他文献

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{{ truncateString('TATSUYA HIGASHI', 18)}}的其他基金

MEASUREMENTS FOR TUMOR BLOOD FLOW BY PET USING H2O IN LUNG CANCER
使用 H2O 测量肺癌中的肿瘤血流
  • 批准号:
    6263709
  • 财政年份:
    1998
  • 资助金额:
    $ 0.02万
  • 项目类别:
MEASUREMENTS FOR TUMOR BLOOD FLOW BY PET USING H2O IN LUNG CANCER
使用 H2O 测量肺癌中的肿瘤血流
  • 批准号:
    6297066
  • 财政年份:
    1998
  • 资助金额:
    $ 0.02万
  • 项目类别:

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