FACTORS IN ANGIOGENESIS OF KAPOSI'S SARCOMA CELLS

卡波西肉瘤细胞血管生成的因素

• 批准号: 6297009
• 负责人: PETER John POLVERINI
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297009
• 关键词: AIDS; Chordata; Kaposi's sarcoma; angiogenesis; cell growth regulation; cell proliferation; disease /disorder etiology; hepatocyte growth factor; medical complication; pathologic process

Kaposi's sarcoma (KS) is one of the most common and lethal sequela of acquired immunodeficiency syndrome (AIDS). Scatter factor (SF), a mesenchymal cell-derived cytokine, also known as hepatocyte growth factor, is a major constituent of HIV infected T lymphocyte conditioned media (HTLV-II CM). We hypothesize that SF plays a central role in the etiology and pathogenesis of AIDS associated KS by 1) inducing phenotypic conversion of EC that have been "initiated" by AIDS associated infectious agents, i.e. the HHV8 virus, 2) by promoting the clonal expansion of phenotypically converted/initiated EC and 3) sustaining the growth of established KS by stimulating tumor cell proliferation and neovascularization.

卡波西肉瘤(KS)是获得性免疫缺陷综合征(AIDS)最常见、最致命的后遗症之一。散射因子(SF)是一种间充质细胞来源的细胞因子，又称肝细胞生长因子，是HIV感染的T淋巴细胞条件培养液(HTLV-II CM)的主要成分。我们推测，SF在艾滋病相关KS的病因和发病机制中发挥核心作用：1)诱导由艾滋病相关感染物(即HHV8病毒)“启动”的EC的表型转换；2)促进表型转换/启动的EC的克隆性扩张；3)通过刺激肿瘤细胞增殖和新生血管维持已建立的KS的生长。