课题基金 / 基金详情

FACTORS IN ANGIOGENESIS OF KAPOSI'S SARCOMA CELLS

FACTORS IN ANGIOGENESIS OF KAPOSI'S SARCOMA CELLS
卡波西肉瘤细胞血管生成的因素
批准号：
6297009
负责人：
PETER John POLVERINI
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6297009
关键词：
AIDS Chordata Kaposi's sarcoma angiogenesis cell growth regulation cell proliferation disease /disorder etiology hepatocyte growth factor medical complication pathologic process

项目摘要

项目成果

PETER John POLVERINI的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Kaposi's sarcoma (KS) is one of the most common and lethal sequela of acquired immunodeficiency syndrome (AIDS). Scatter factor (SF), a mesenchymal cell-derived cytokine, also known as hepatocyte growth factor, is a major constituent of HIV infected T lymphocyte conditioned media (HTLV-II CM). We hypothesize that SF plays a central role in the etiology and pathogenesis of AIDS associated KS by 1) inducing phenotypic conversion of EC that have been "initiated" by AIDS associated infectious agents, i.e. the HHV8 virus, 2) by promoting the clonal expansion of phenotypically converted/initiated EC and 3) sustaining the growth of established KS by stimulating tumor cell proliferation and neovascularization.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ANGIOGENESIS, ENDOTHELIAL SURVIVAL, AND ORAL CANCER
ANGIOGENESIS, ENDOTHELIAL SURVIVAL, AND ORAL CANCER
  • 批准号：
    6523874
  • 项目类别：
  • 资助金额：
    $17.99万
  • 财政年份：
    1999
  • 负责人：
    PETER John POLVERINI
  • 依托单位：
    UNIVERSITY OF MINNESOTA
ANGIOGENESIS, ENDOTHELIAL SURVIVAL, AND ORAL CANCER
  • 批准号：
    6175898
  • 项目类别：
  • 资助金额：
    $28.17万
  • 财政年份：
    1999
  • 负责人：
    PETER John POLVERINI
  • 依托单位：
    UNIVERSITY OF MINNESOTA
ANGIOGENESIS, ENDOTHELIAL SURVIVAL, AND ORAL CANCER
海外基金