FACTORS IN ANGIOGENESIS OF KAPOSI'S SARCOMA CELLS

卡波西肉瘤细胞血管生成的因素

• 批准号: 6244693
• 负责人: PETER John POLVERINI
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244693
• 关键词: AIDS related neoplasm /cancer; Kaposi's sarcoma; angiogenesis; cell proliferation; hepatocyte growth factor; neoplastic cell; opportunistic infections; pathologic process; tissue /cell culture

Kaposi's sarcoma (KS) is one of the most common and lethal sequela of acquired immunodeficiency syndrome (AIDS). Scatter factor (SF), a mesenchymal cell-derived cytokine, also known as hepatocyte growth factor, is a major constituent of HIV infected T lymphocyte conditioned media (HTLV-II CM). We hypothesize that SF plays a central role in the etiology and pathogenesis of AIDS associated KS by 1) inducing phenotypic conversion of EC that have been "initiated" by AIDS associated infectious agents, i.e. the HHV8 virus, 2) by promoting the clonal expansion of phenotypically converted/initiated EC and 3) sustaining the growth of established KS by stimulating tumor cell proliferation and neovascularization.

卡波西肉瘤（KS）是最常见、最致命的后遗症之一 获得性免疫缺陷综合症（艾滋病）。散射因子 (SF)，a 间充质细胞衍生的细胞因子，也称为肝细胞生长 因子，是HIV感染的T淋巴细胞条件化的主要成分 媒体（HTLV-II CM）。 我们假设 SF 在 艾滋病相关 KS 的病因和发病机制由 1) 诱发 由艾滋病“引发”的 EC 表型转变 相关感染因子，即 HHV8 病毒，2) 通过促进 表型转化/启动的 EC 的克隆扩增和 3) 通过刺激肿瘤细胞维持已建立的 KS 的生长 增殖和新血管形成。