NITROGEN BALANCE AND AMINO ACID CLEARANCE IN PEDIATRIC PATIENTS WITH ARF ON CRRT

CRRT 上 ARF 儿科患者的氮平衡和氨基酸清除率

• 批准号: 6113485
• 负责人: TIMOTHY E BUNCHMAN
• 金额: $ 2.14万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6113485
• 关键词: acute renal failure; aminoacid metabolism; child (0-11); clearance rate; clinical research; clinical trials; diet therapy; dietary proteins; dosage forms; human subject; human therapy evaluation; nitrogen balance; nutrient intake activity; nutrition related tag; parenteral feedings; pediatrics; tube feeding

Meeting nutritional needs in critically ill patients is a primary concern in their management and recovery. Nitrogen balance for these patients by adequate protein intake through enteral/parenteral nutrition is a key aim. How much Nitrogen intake and the Amino Acid (AA) composition fo this protein in patients with acute renal failure (ARF) is not clearly established. Adjustments in the protein intake of the patient for the form of RRT (renal replacement therapy) is often necessary. An increasingly common form of RRT in ARF is Continuous Venovenous Hemofiltration (CVVH). Two forms are commonly used: CVVH with FRF (filtered renal failure) and CVVHD (continuous venovenous diafiltration). This project's objective will be to evaluate pediatric patients on CRRT for Amino Acid Clearance by both modalities (CCVH + FRF vs. CVVHD) to determine its effect on nitrogen balance.

满足危重病人的营养需求是首要的 在他们的管理和恢复方面的关切。这些植物的氮素平衡 通过肠内/肠外摄入足够蛋白质的患者 营养是一个关键目标。氮的摄入量与氨基酸 (AA)急性肾功能衰竭患者这种蛋白的组成 (ARF)没有明确确立。蛋白质摄入量的调节 接受RRT(肾脏替代疗法)形式的患者通常 这是必要的。在ARF中，RRT的一种日益常见的形式是连续性 静脉静脉血液滤过(CVVH)。通常使用两种形式：CVVH FRF(滤过性肾功能衰竭)和CVVHD(持续静脉-静脉 透析过滤)。该项目的目标将是评估儿科 两种方式(CCVH+FRF)对CRRT患者的氨基酸清除作用 Vs.CVVHD)，以确定其对氮平衡的影响。