NITROGEN BALANCE AND AMINO ACID CLEARANCE IN PEDIATRIC PATIENTS WITH ARF ON CRRT

CRRT 上 ARF 儿科患者的氮平衡和氨基酸清除率

• 批准号: 6244711
• 负责人: TIMOTHY E BUNCHMAN
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244711
• 关键词: acute renal failure; aminoacid metabolism; child (0-11); clearance rate; clinical research; diet therapy; dietary proteins; dosage forms; human subject; human therapy evaluation; nitrogen balance; nutrient intake activity; nutrition related tag; parenteral feedings; pediatrics; tube feeding

Meeting nutritional needs in critically ill patients is a primary concern in their management and recovery. Nitrogen balance for these patients by adequate protein intake through enteral/parenteral nutrition is a key aim. How much Nitrogen intake and the Amino Acid (AA) composition fo this protein in patients with acute renal failure (ARF) is not clearly established. Adjustments in the protein intake of the patient for the form of RRT (renal replacement therapy) is often necessary. An increasingly common form of RRT in ARF is Continuous Venovenous Hemofiltration (CVVH). Two forms are commonly used: CVVH with FRF (filtered renal failure) and CVVHD (continuous venovenous diafiltration). This project's objective will be to evaluate pediatric patients on CRRT for Amino Acid Clearance by both modalities (CCVH + FRF vs. CVVHD) to determine its effect on nitrogen balance.

满足危重病人的营养需求是一个主要的 关注他们的管理和恢复。 氮平衡对于这些 通过肠内/肠外营养摄入充足蛋白质的患者 是一个关键目标。 氮摄入量和氨基酸（AA） 急性肾功能衰竭（ARF）患者中该蛋白的组成 没有明确规定。 在蛋白质摄入量的调整 RRT（肾脏替代疗法）形式的患者通常 必要 ARF中一种越来越常见的RRT形式是持续性RRT 静脉血液滤过（CVVH）。 通常使用两种形式：CVVH FRF（滤过性肾衰竭）和CVVHD（连续静脉-静脉 渗滤）。 该项目的目标是评估儿科 两种模式（CCVH + FRF）下接受CRRT进行氨基酸清除的患者 vs. CVVHD），以确定其对氮平衡的影响。