AstraZeneca Secondment for Clinical Pharmacology Training

阿斯利康借调临床药理学培训

• 批准号: MR/W003538/1
• 负责人: Joseph Cheriyan
• 金额: $ 6.24万
• 依托单位: Cambridge University Hospitals NHS Foundation Trust
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW003538%2F1
• 关键词: AstraZeneca; Secondment; Clinical; Pharmacology; Training

This proposal will provide funding for a trainee doctor to spend 9 months working on clinical trials in the biopharmaceutical industry. Trainee doctors in the NHS are required to undertake specialist training as set out in a training curriculum. However, a number of training activities related to clinical trials are not easily accessible within an NHS setting. The biopharmaceutical industry has a wealth of experience of designing and running early phase clinical trials, so this is an ideal setting in which to undertake training. The pharmaceutical company AstraZeneca (AZ) has offered to host a trainee doctor for a 9 month placement. This would involve working with a clinical project team to gain experience in a range of activities involved in the design, set up and running of an early phase clinical trial. The trial in question would look at the safety and effectiveness of drugs to treat increased blood pressure in the blood vessels that lead to the liver. This is often caused by liver cirrhosis. There have been no new treatments in this disease area for over 20 years and complication rates are high even with existing treatments, so this is an important trial.In addition to providing clinical trial experience, this placement will also provide wider access to the whole development pathway for new medicines. There will also be opportunities to interact with other early career researchers through a wide range of scientific meetings and events, plus leadership and management training. In this way, the placement creates a unique opportunity for growth of the trainee's skills, knowledge and professional network which will enhance downstream career choices. In return, the trainee doctor would bring to industry specialist expertise and clinical insight gained through working within the NHS at Addenbrooke's Hospital. This will be extremely useful when designing and running the proposed clinical trial for cardiovascular and liver disease.With their close geographical location, this placement will create a unique opportunity for AZ, the University and the NHS to work together in Cambridge to develop professional skills and talent. By encouraging transfer of staff and sharing of knowledge between different sectors, it will, in turn, promote career development for the trainee doctor. Collectively, these factors align closely with the aims of the UKRI Innovation Scholars programme bringing a range of benefits to the wider biomedical sciences sector.

这项提案将为一名实习医生提供资金，让他在生物制药行业花9个月的时间进行临床试验。国民保健制度中的见习医生必须接受培训课程中规定的专科培训。然而，许多与临床试验相关的培训活动在NHS环境下并不容易获得。生物制药行业在设计和运行早期临床试验方面拥有丰富的经验，因此这是进行培训的理想环境。制药公司阿斯利康(AZ)提出招待一名实习医生，为期9个月。这将涉及与临床项目团队合作，在设计、建立和运行早期临床试验所涉及的一系列活动中获得经验。这项有问题的试验将着眼于治疗通往肝脏的血管中血压升高的药物的安全性和有效性。这通常是由肝硬变引起的。这个疾病领域已经20多年没有新的治疗方法了，即使是现有的治疗方法，并发症的发生率也很高，所以这是一项重要的试验。除了提供临床试验经验外，这种安置也将为新药的整个开发途径提供更广泛的途径。还将有机会通过广泛的科学会议和活动，以及领导力和管理培训，与其他早期职业研究人员互动。通过这种方式，就业机会为学员的技能、知识和专业网络的增长创造了一个独特的机会，这将增强下游的职业选择。作为回报，实习医生将为医疗行业带来通过在阿登布鲁克医院的NHS工作中获得的专业知识和临床洞察力。这在设计和运行拟议的心血管和肝脏疾病临床试验时将非常有用。由于地理位置接近，这一安排将为AZ、大学和NHS在剑桥合作发展专业技能和人才创造一个独特的机会。通过鼓励不同部门之间的工作人员调动和知识分享，这将反过来促进见习医生的职业发展。总体而言，这些因素与UKRI创新学者计划的目标密切一致，为更广泛的生物医学科学部门带来了一系列好处。

项目成果

Quo vadis (where are you going) pharmacovigilance?

Quo vadis（你要去哪里）药物警戒？

• DOI: 10.1111/bcp.15584
• 发表时间: 2023
• 期刊: British journal of clinical pharmacology
• 影响因子: 3.4
• 作者: Kulkarni S

Metabolic adverse events associated with systemic corticosteroid therapy-a systematic review and meta-analysis.

• DOI: 10.1136/bmjopen-2022-061476
• 发表时间: 2022-12-22
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Kulkarni, Spoorthy;Durham, Hannah;Glover, Luke;Ather, Osaid;Phillips, Veronica;Nemes, Szilard;Cousens, Leslie;Blomgran, Parmis;Ambery, Philip
• 通讯作者: Ambery, Philip