DIETARY APPROACHES TO STOP HYPERTENSION 2 (DASH 2)

控制高血压的饮食方法 2 (DASH 2)

• 批准号: 6114386
• 负责人: LAWRENCE JOHN APPEL
• 金额: $ 2.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114386
• 关键词: clinical research; diet therapy; disease /disorder prevention /control; human subject; human therapy evaluation; hypertension; lipid peroxides; nutrition related tag; peroxidation; urinalysis

The objective of this ancillary study in DASH2 is to determine the impact of dietary patterns on rates of lipid peroxidation, serum antioxidant activity, and indicators of LDL-cholesterol oxidation, and to chart their time course. The DASH2 trial provides the infrastructure for the proposed research. DASH2 is a feeding study designed to assess the effects of 3 salt levels in 2 dietary patterns on blood pressure in 100 adults with systolic blood pressure 120-159 mmHg and diastolic blood pressure 80 to 95 mmHg. For two weeks, participants are fed a control diet, low in fruits, vegetables, and dairy products, with fat and salt content typical of US consumption. Participants are then randomized in a parallel arm design to (1) the control diet or (2) a "combination" diet rich in fruits, vegetables, and low-fat dairy products, and reduced in saturated and total fat. Within each diet, participants receive three different sodium levels (50 mmol/d, 100 mmol/d, and 150 mmol/d), each for 30 days. Study participants will be the 100 healthy volunteers to be enrolled in DASH2 at the Johns Hopkins General Clinical Research Center. To date, we have collected blood and urine specimens from 35 randomized participants enrolled in the first of three feeding cohorts. Sampling of blood and urine will take place, in addition to the baseline measurement (prior to randomization), at the end of each 30 day period. The primary outcome measures, which are measures of oxidative damage, include urinary isoprostanes and malondialdehyde and serum antibodies to oxidized LDL. The proposed study has the potential to enhance our basic understanding of the mechanisms by which diet affects these important intermediaries of cardiovascular disease.

DASH2的这项辅助研究的目的是确定 膳食结构对血清脂质过氧化水平的影响 抗氧化活性和低密度脂蛋白-胆固醇氧化指标，以及 来绘制他们的时间进程。DASH2试验提供了基础设施 用于拟议的研究。DASH2是一项喂养研究，旨在评估 两种膳食模式中三种盐分水平对血压的影响 100名成年人，收缩压120-159毫米汞柱，舒张压 压力80至95毫米汞柱。在两周的时间里，参与者被喂食一组对照 饮食，水果、蔬菜和乳制品含量低，含脂肪和盐 美国消费的典型内容。参与者随后被随机分配到 平行臂设计，以(1)控制饮食或(2)“组合” 饮食中富含水果、蔬菜和低脂乳制品，减少 饱和脂肪和总脂肪。在每种饮食中，参与者都会收到 三种不同的钠水平(50、100和150 mmol/d)， 每次30天。 这项研究的参与者将是100名健康志愿者 约翰霍普金斯综合临床研究中心的DASH2博士说。到目前为止， 我们随机收集了35份血液和尿液样本 参与者参加了三个喂养队列中的第一个。抽样 除了基线外，还将进行血液和尿液的检测 测量(在随机化之前)，在每30天周期结束时进行。 主要的结果指标，即氧化损伤的指标， 包括尿异前列腺素、丙二醛和血清抗体 氧化的低密度脂蛋白。 拟议的研究有可能增进我们的基本了解 饮食影响这些重要中介的机制 心血管疾病。