区分滤泡性腺瘤/滤泡性癌的分子机制-猫眼课题宝

区分滤泡性腺瘤/滤泡性癌的分子机制

批准号：

6218204

负责人：

MARTHA A ZEIGER

金额：

$0.23万

依托单位：

JOHNS HOPKINS UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-12-01 至 1999-11-30

来源：

https://reporter.nih.gov/project-details/6218204

关键词：

adenoma biomarker carcinoma chromosome aberrations clinical research cytology diagnosis design /evaluation diagnosis quality /standard enzyme activity human subject loss of heterozygosity molecular oncology neoplasm /cancer diagnosis nucleic acid repetitive sequence telomerase thyroid neoplasm

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英文摘要

Over 28,000 thyroidectomies are performed in the United States annually for suspected malignancy. However, up to 18,000 of these are benign on permanent histology. This phenomenon is due to the fact that fine needle aspirations (FNA) of the thyroid that are suspicious for malignancy ultimately turn out to represent a benign process in 60% of cases. Because of this phenomenon we chose to examine follicular neoplasms of the thyroid for molecular markers that would distinguish a follicular adenoma from a carcinoma.

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