IGE ISOFORMS IN FOOD INDUCED ATOPIC DERMATITIS IN CHILDREN

食物引起的儿童特应性皮炎中的 IGE 同工酶

• 批准号: 6263981
• 负责人: ANDY H LIU
• 金额: $ 3.22万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263981
• 关键词: B lymphocyte; atopic dermatitis; blood chemistry; cell differentiation; child (0-11); clinical research; cytokine; food hypersensitivity; human subject; immunoglobulin E; lectin; peanuts; protein isoforms

This study as part of the GCRC is to better understand the IgE-mediated mechansisms of food allergies and, in particular, of food-induced atopic dermatitis. We have obtained blood donations from subject, of which one was food - challenged as part of the protocol. As part of our investigation, we became particularily interested in the role that lectin flycoproteins, such as peanut agglutinin (PNA), may have in the development of food allergies such as peanut allergy. We have been able to define specific conditions that upregulate PNA binding by lymphyocytes. We are currently refining our understanding of these conditions, in order to determine if PNA can co-stimulate B lymphycyte differnatation to induce cytokine secreation and/or IgE synthesis. An abstract of this work has been accepted for presentation at the 1999 AAAAI Annual Meeting. If these studies continue to be promising, then we will continue this protocol to determine if subjects with atopic dermatitis may be predisposed to co-stimulation of IgE production by PNA.

作为GCRC的一部分，本研究旨在更好地了解ige介导的食物过敏机制，特别是食物诱发的特应性皮炎。我们已经获得了受试者的血液捐献，其中一名受试者是缺食症患者，这是协议的一部分。作为我们调查的一部分，我们对凝集素蝇蛋白，如花生凝集素（PNA），在花生过敏等食物过敏的发展中可能起的作用特别感兴趣。我们已经能够确定特定的条件，上调PNA结合淋巴细胞。我们目前正在完善我们对这些条件的理解，以确定PNA是否可以共同刺激B淋巴细胞分化，诱导细胞因子分泌和/或IgE合成。这项工作的摘要已被接受在1999年AAAAI年会上发表。如果这些研究继续有希望，那么我们将继续这个方案，以确定是否有特应性皮炎的受试者可能倾向于PNA共同刺激IgE的产生。